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Aniracetam
Fat-soluble racetam that modulates AMPA receptors for cognitive enhancement while reducing anxiety through serotonin and dopamine pathways.
What the evidence says
Most Aniracetam studies are mechanism or observational rather than RCTs that measure a clinical effect — keep findings provisional.
Most evidence is from high-quality meta-analyses and randomised trials published 2007–2020 with a typical study size of 88 participants.
Based on 9 studies · 1 meta-analysis · 5 RCTs · 45,513 total participants
Confidence
HighWhat the studies found
By outcome
Aniracetam has an evidence score of 7/10 — strong evidence based on 9 indexed studies, including 1 meta-analysis. Fat-soluble racetam that modulates AMPA receptors for cognitive enhancement while reducing anxiety through serotonin and dopamine pathways.
The commonly studied dose of Aniracetam is 750-1500mg daily in divided doses. Research points to an estimated optimal dose around 1200mg, with a minimum effective dose near 750mg. Individual response varies — start low and adjust.
The best time to take Aniracetam is in the morning. Take it with food. Aniracetam is fat-soluble with a short half-life (~1-2.5 hours).
Phosphatidylserine
Mostly mechanism / observationalKey brain membrane phospholipid that facilitates neurotransmitter release, memory formation, and post-exercise cortisol reduction.
Omega-3
Probably helpsEssential fatty acids critical for brain health, mood regulation, and reducing inflammation throughout the body.
Last reviewed May 2026 · evidence from 14 studies · how we score
This information is for educational purposes only. It is not a substitute for professional medical advice. Always consult a qualified healthcare provider before starting, stopping, or changing any supplement or medication.
Aniracetam is a fat-soluble racetam nootropic that was developed in the 1970s. It's more potent than piracetam and has a unique profile that includes both cognitive enhancement and anxiolytic (anti-anxiety) effects. It works by modulating AMPA receptors, enhancing cholinergic transmission, and affecting dopamine and serotonin systems. The combination of cognitive and mood benefits makes it popular among nootropic users.
Positive modulator of AMPA receptors
Increases acetylcholine activity
Modulates mood neurotransmitters
How Aniracetam works — from molecular targets to health outcomes. Click an edge to see supporting research.This visualization is in beta — pathways are being refined and expanded.
750-1500mg daily in divided doses
Loading: Not required
Take with food
| Form | Type |
|---|---|
| 💊Aniracetam powder or capsules | Recommended |
Available as powder or capsules. Powder has bitter taste. Take with fatty meal or fish oil.
Minimum: 4 weeks
Optimal: 12 weeks
Cycling: 8-12 weeks on, 2-4 weeks off; some use continuously
Note: Fat-soluble; must be taken with food containing fat for proper absorption. Short half-life (1-2 hours) requires multiple daily doses.
Based on limited RCTs (n=166, n=64) and observational studies (n=276) in cognitive impairment populations. Meta-analysis effect size 0.439 suggests moderate benefit. Studies primarily in elderly/dementia patients, not healthy adults. Fat-soluble compound requiring food intake for absorption.
Improved memory, focus, and verbal fluency
Reduced social and general anxiety
Enhanced creative thinking and idea flow
Effects last only 2-3 hours per dose
May provide dual cognitive and anxiolytic benefits
Synergistic effects with other racetams; adjust doses
Tip: Take with choline source
Tip: Take with food
Tip: Avoid evening doses
Aniracetam is generally well-tolerated and considered safe for most healthy adults at recommended doses. The most commonly reported side effects are headache, GI discomfort, insomnia. Use caution if any of these apply to you: Severe kidney impairment.
Piracetam
Likely helpsFirst-ever nootropic (1972) that improves membrane fluidity and AMPA receptor function — decades of safety data for cognitive enhancement.
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