Browse 225 evidence-based supplements
Blocks adenosine receptors to boost alertness, reaction time, and endurance — one of the most proven ergogenic aids.
Increases phosphocreatine stores for faster ATP regeneration, boosting strength, power output, and cognitive function under stress.
Primary substrate for nitric oxide production — dilates blood vessels to improve circulation, exercise performance, and cardiovascular health.
Essential B vitamins in their active methylated forms, supporting energy production, mood, and cognitive function.
Leucine, isoleucine, and valine metabolized directly in muscle tissue — support protein synthesis and reduce exercise fatigue.
Forms a stomach gel for 6-8 hours of sustained amino acid release — ideal for overnight muscle recovery and anti-catabolism.
Replenish the lipids that make up 50% of the skin barrier — oral phytoceramides restore hydration and reduce wrinkles from within.
Precursor to acetylcholine and phosphatidylcholine — critical for memory, liver function, and cell membrane integrity.
Hydrolyzed peptides that rebuild skin elasticity, reduce joint pain, and strengthen bone density — results build over 8-12 weeks.
Cofactor for iron metabolism, connective tissue synthesis, and superoxide dismutase — must be balanced with zinc intake.
Enhances mitochondrial energy production and acts as a lipid-soluble antioxidant — critical for heart health and depleted by statins.
Turmeric's active compound that modulates NF-kB inflammatory pathways — supports mood, joint health, and post-exercise recovery.
Adrenal hormone precursor that declines with age, supporting hormone balance, energy, and body composition.
Reduces cold risk and shortens infection duration — most effective when started at first sign of symptoms.
Essential minerals for hydration, muscle function, and performance — crucial for athletes, fasters, and those on low-carb diets.
Improves cerebral blood flow and peripheral circulation — modest evidence for memory in older adults and cognitive decline.
Concentrated catechins from green tea that support metabolism, fat oxidation, brain health, and antioxidant defense.
Essential trace mineral for thyroid hormone production — deficiency is common and affects metabolism, energy, and cognition.
Essential mineral for oxygen transport and energy production — critical for those with deficiency, especially women and athletes.
Kavalactones produce anxiolytic and muscle-relaxing effects comparable to prescription anti-anxiety medications in clinical trials.
Amino acid that boosts nitric oxide production, improving blood flow, exercise performance, and recovery.
Primary fuel for intestinal and immune cells — becomes conditionally essential during stress, illness, or intense training.
Bypasses normal fat digestion to convert directly to ketones in the liver — provides rapid energy for brain and body.
NAD+ precursor that raises HDL, lowers LDL and triglycerides, and fuels cellular energy metabolism at therapeutic doses.
Essential fatty acids critical for brain health, mood regulation, and reducing inflammation throughout the body.
Ginsenosides combat fatigue, sharpen cognitive function, and enhance stress resilience — distinct from American and Siberian ginseng.
Proanthocyanidin-rich extract that improves blood flow, skin elasticity, and cognitive function — backed by 160+ published studies.
Primary intracellular electrolyte that regulates blood pressure, nerve transmission, and muscle contraction — works in balance with sodium.
Live microorganisms where strain selection determines outcome — Lactobacillus and Bifidobacterium strains best studied for gut, immune, and mood.
Drives 100+ methylation reactions including neurotransmitter synthesis — clinically validated for depression, osteoarthritis, and liver health.
Plant compounds with weak estrogenic effects that support menopausal symptoms, bone health, and cardiovascular function.
Converts carbohydrates into cellular energy and supports acetylcholine synthesis for healthy nerve and brain function.
Fat-soluble vitamin that maintains night vision, drives immune cell differentiation, and regulates skin turnover and cellular growth.
Cofactor in 100+ enzyme reactions including serotonin, dopamine, and GABA synthesis — also lowers homocysteine levels.
Hormone-like vitamin that regulates 1,000+ genes — deficiency is widespread and linked to poor immunity, depression, and bone loss.
Lipid-soluble antioxidant that shields cell membranes from oxidative damage — natural mixed tocopherols preferred over synthetic forms.
Complete protein with high leucine content that maximizes muscle protein synthesis — most researched protein supplement worldwide.
Involved in 300+ enzymatic reactions — supports immune defense, testosterone production, wound healing, and sleep quality.
Builds and maintains bone density while supporting muscle contraction, nerve signaling, and cardiovascular function.
Direct serotonin precursor that may support mood, sleep, and appetite control, but requires caution with certain medications.
Crosses the blood-brain barrier to fuel acetylcholine synthesis — supports focus, memory, and power output in athletes.
Fat-soluble form of vitamin B1 with superior absorption that protects against glycation and supports nerve health.
Citrus extract with compelling evidence for cholesterol management, particularly LDL reduction and improved lipid ratios.
Plant sterol that reduces BPH urinary symptoms in clinical trials and blocks intestinal cholesterol absorption.
Cofactor for fatty acid synthesis and gluconeogenesis — strongest evidence for brittle nail syndrome and keratin infrastructure support.
Potent anti-inflammatory resin extract with strong evidence for joint pain, arthritis, and inflammatory conditions.
Short-chain fatty acid postbiotic that feeds gut lining cells, reduces inflammation, and supports the gut-brain axis.
Emerging longevity compound that may reduce biological age markers, support cellular energy, and extend healthspan.
Improves ATP production and oxygen uptake during exercise — traditionally prized for boosting energy and endurance capacity.
Shifts estrogen metabolism toward beneficial 2-hydroxy metabolites, reducing harmful estrogen dominance in both men and women.
Promotes blood circulation and menstrual regularity — a cornerstone of Chinese medicine for women's health for 2,000+ years.
Dark chocolate flavonoid that inhibits myostatin and boosts follistatin, supporting muscle growth, endurance, and cardiovascular health.
Inhibitory neurotransmitter that calms neural activity — may work through the gut-brain axis for acute anxiety and sleep support.
Sacred Ayurvedic adaptogen that helps the body manage stress, supports metabolic health, and promotes mental clarity.
Precursor to phosphatidylserine, glycine, and D-serine — studied at high doses for neuroprotection in ALS and myelin formation.
Mint-family herb that modulates GABA for mild anxiety relief and sleep support — well-suited for daily use without sedation.
Crosses the blood-brain barrier to reduce neuroinflammation and inhibits mast cell activation — useful for allergies and brain health.
Supports 300+ enzymatic reactions — critical for sleep, stress response, muscle function, and cognitive health.
Organic sulfur donor for connective tissue repair — reduces joint inflammation and supports post-exercise recovery and flexibility.
Enzyme from Japanese fermented soybeans that supports healthy blood flow and may help break down fibrin.
NAD+ precursor backed by strong clinical evidence for boosting cellular energy and supporting healthy aging.
Accelerates ammonia clearance through the urea cycle, reducing exercise-induced fatigue and supporting recovery during prolonged efforts.
Naturally occurring fatty acid that supports pain relief and reduces inflammation through the endocannabinoid system.
Key brain membrane phospholipid that facilitates neurotransmitter release, memory formation, and post-exercise cortisol reduction.
Precursor to all steroid hormones (DHEA, progesterone, cortisol, testosterone) that also acts as a neurosteroid supporting cognition and mood.
Gel-forming soluble fiber that lowers LDL cholesterol, regulates blood sugar, and promotes digestive regularity.
Fast-acting adaptogen that combats mental fatigue and improves cognitive performance under stress — works within days, not weeks.
Five-flavor adaptogenic berry with rare hepatoprotective properties — supports liver detoxification, mental clarity, and physical endurance.
Herbal support for prostate health and urinary symptoms, often combined with saw palmetto for BPH.
Natural melatonin and anthocyanin source that uniquely addresses both sleep quality and post-exercise recovery simultaneously.
Saponin-rich herb that consistently improves libido and sexual function, though evidence for testosterone elevation remains weak.
Water-soluble bile acid that protects the liver, supports bile flow, reduces ER stress, and aids digestion of fats.
Postbiotic that triggers mitophagy — the cleanup of damaged mitochondria — to support muscle health and cellular energy.
Humans cannot synthesize this vitamin — required for collagen production, immune cell function, and iron absorption; athletes need more.
Contains charantin and polypeptide-p with insulin-mimicking activity — lowers blood glucose through multiple mechanisms.
Flavonoid with potent senolytic properties, may clear damaged cells and support healthy aging.
Leucine metabolite that helps prevent muscle breakdown and supports recovery, especially during caloric restriction or intense training.
Vitamin-like compound that supports mood, sleep, and hormonal balance, with strong evidence for anxiety, OCD, and PCOS.
Rich in unique D-fraction beta-glucans that modulate immune function and help regulate blood sugar levels.
Calms anxiety-related heart palpitations and rapid heartbeat while providing mild sedative and menstrual support effects.
Rate-limiting precursor to glutathione, the body's master antioxidant — supports mood, respiratory health, and liver protection.
Unique compound that promotes the growth of new mitochondria, supporting cellular energy and brain health.
Patented pine bark extract with over 400 studies supporting benefits for circulation, skin, cognitive function, and joint health.
Isoflavone-rich plant with weak estrogenic activity that reduces hot flashes and supports bone density and arterial flexibility.
Clinically matched low-dose SSRIs for mild-to-moderate depression — also reduces anxiety and PMS symptoms.
Himalayan mineral pitch rich in fulvic acid and 80+ minerals — supports testosterone, mitochondrial function, and cellular energy.
Proven ergogenic aid that buffers lactic acid, extending high-intensity exercise capacity by 1-3%.
Sole dietary precursor to serotonin and melatonin — supports mood regulation and natural sleep onset more gradually than 5-HTP.
A Mediterranean herb with rosmarinic acid and salvianolic compounds that support cognitive function, menopausal symptom relief, and metabolic health through antioxidant and cholinergic mechanisms.
Reduces cortisol and anxiety while improving sleep quality and physical recovery in stressed adults.
Carotenoid from algae that spans cell membranes for full-spectrum protection — studied for skin, eye health, and exercise recovery.
Dietary nitrates convert to nitric oxide, enhancing oxygen delivery to muscles — a top-5 evidence-based ergogenic aid.
Increases muscle carnosine to buffer acid during high-intensity exercise, extending endurance for 1-4 minute efforts.
Leading herb for menopause symptoms, particularly hot flashes, with evidence comparable to low-dose estrogen for some women.
Inhibits drug-metabolizing enzymes to boost absorption of curcumin, CoQ10, and other supplements by up to 2,000%.
Blocks protein glycation and buffers muscle pH, supporting longevity, exercise performance, and cognitive function.
First milk rich in immunoglobulins, growth factors, and antimicrobial compounds that supports gut health, immunity, and recovery.
Five-carbon sugar that forms the backbone of ATP — accelerates cellular energy recovery in heart and muscle tissue.
Complete essential amino acid blend that maximizes muscle protein synthesis — superior to BCAAs alone.
Traditional herb with evidence for supporting testosterone, libido, blood sugar control, and lactation.
Hyperhydrating agent that pulls extra fluid into tissue before competition — improves endurance and thermoregulation in heat.
Traditional heart tonic with evidence for mild heart failure, blood pressure support, and cardiovascular health.
Inhibits acetylcholinesterase to raise acetylcholine levels, enhancing memory formation, focus, and learning capacity.
Converts to DIM in the stomach, shifting estrogen metabolism toward favorable 2-hydroxy metabolites for hormonal balance.
A multifunctional iron-binding glycoprotein from milk with broad antimicrobial, anti-inflammatory, and immune-modulating properties.
Traditional Chinese herb that reduces cortisol, supports sleep, and promotes relaxation without sedation.
Cofactor for mitochondrial superoxide dismutase (MnSOD) and enzymes involved in bone formation, blood clotting, and macronutrient metabolism.
Fermented rice containing natural statins that effectively lower LDL cholesterol — the original statin.
Contains unique 10-HDA fatty acid and royalactin — supports skin health, cholesterol, blood sugar, and menopausal symptoms.
Concentrated in heart, brain, and muscle — emerging longevity data alongside proven benefits for sleep, cardiovascular function, and recovery.
Purine alkaloid that activates adenosine and dopamine pathways for sustained energy — no tolerance buildup or jitteriness.
Fat-soluble vitamin that directs calcium to bones instead of arteries, supporting cardiovascular and bone health.
Leading herb for women's hormonal balance, with strong evidence for PMS relief and menstrual cycle regulation.
Nutritional insurance that fills micronutrient gaps — COSMOS trial showed benefits for memory, cancer risk reduction, and immune function.
A vitamin B3 precursor that efficiently raises cellular NAD+ levels, supporting energy metabolism, mitochondrial function, and healthy aging.
Arginine metabolite that modulates NMDA receptors and nitric oxide — supports mood, pain management, and neuroprotection.
Nutrient-dense bee product containing complete proteins, enzymes, and flavonoids that support energy, immunity, and recovery.
Proteolytic enzyme from pineapple that aids digestion with food or provides systemic anti-inflammatory and recovery benefits on an empty stomach.
One of nature's highest antioxidant sources, containing melanin and betulinic acid for immune and inflammatory support.
Adaptogen that supports endurance, stress resilience, and immune function — distinct from true ginseng.
Triterpenoid-rich herb that enhances collagen synthesis, supports neuroprotection, and reduces anxiety — unrelated to kola nut.
Contains L-DOPA, the direct dopamine precursor — supports mood, motivation, and reproductive health but requires careful dosing.
Methylated resveratrol analog with 4x better bioavailability — activates sirtuins for longevity, cognition, and metabolic benefits.
Beta-glucan and triterpene-rich mushroom with calming properties that supports immune function, sleep quality, and stress resilience.
Southeast Asian herb with evidence for supporting healthy testosterone levels, energy, and stress resilience.
Immune-supporting mushroom with the strongest evidence among medicinal mushrooms, used as cancer therapy adjunct in Asia.
Amino acid precursor to dopamine and norepinephrine, supporting focus and mental performance under stress.
Recovery-optimized form of carnitine with evidence for muscle recovery, androgen receptor upregulation, and exercise performance.
A cold-pressed oil rich in phytosterols, zinc, and unsaturated fatty acids shown to support prostate health, hair growth, cardiovascular function, and hormonal balance.
A natural herb with anti-androgenic, anti-inflammatory, and cognitive-enhancing properties, particularly studied for hormonal balance in women and memory support.
Relaxes smooth muscle tissue through scopoletin compounds, primarily used for menstrual cramps and muscle spasms.
30-60x more potent than piracetam — developed for cosmonauts, banned by WADA for its cognitive and physical performance effects.
Synthetic peptide ~1,000x more potent than piracetam that boosts NGF and BDNF for memory, learning, and neuroprotection.
Calming herb that supports relaxation and sleep through GABA modulation — gentler than valerian with less morning grogginess.
Rare old-growth mushroom with antiviral compounds studied for immune defense — one of the oldest medicinal fungi known to science.
Nigerian shrub with preliminary evidence for testosterone and libido support — popular but human research is still very limited.
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