The Use of Zoledronic Acid to Prevent Cancer-treatment Bone Loss in Post-menopausal Women Receiving Adjuvant Letrozole for Breast Cancer
· ClinicalTrials.gov
Find supplements that actually work
Most supplement sites want to sell you something. SupStack just helps you figure out what's backed by real research — and what's not worth your money.
583+ supplements44,440+ studies100% free
New to supplements?
Take the 2-minute Quiz
Pick your goals — we'll match you with evidence-backed supplements and build you a personalized stack.
Build my planAlready have a stack?Get an instant grade
Paste your supplements — we'll grade the stack, flag interactions and gaps, and check your doses against studied ranges. 30 seconds, no signup.
Check My StackHow it works
From research to results in four steps
1
Pick your goals
Sleep, focus, recovery, energy — whatever you're trying to improve.
3
Build your stack
See how supplements connect to outcomes through biological pathways and build your personalised stack.
4
Run experiments
Track your personal response with N-of-1 experiments and get a verdict.
Browse by goal
Find the best-evidenced supplements for what you're trying to improve
Best supplements for Sleep
Best supplements for Athletic Performance
Best supplements for Focus, Memory & Mood
Best supplements for Vitality & Longevity
Best supplements for Body Health
Best supplements for Women's Health
Best supplements for Men's Health
Best supplements for Skin, Hair & Beauty
See all goals
Popular head-to-head comparisons
Evidence-based, side-by-side breakdowns of the supplements people compare most.
Trusted by the community
Join researchers, biohackers, and health-conscious people making evidence-based decisions
500+
Quiz completions
1,200+
Stacks built
44,440+
Peer-reviewed studies analyzed
What makes SupStack different
Research, not marketing
Every supplement is rated based on actual clinical studies — not influencer posts or manufacturer claims.
Sources you can check
Every rating links back to PubMed studies. Don't take our word for it — read the research yourself.
Safety info upfront
Drug interactions, side effects, and who should avoid what — the stuff that's usually buried in fine print.
Continuously validated
Every claim is cross-checked against real studies. Scores and safety ratings get updated as new research comes out.
Ready-made stacks
25 evidence-based, pre-built supplement stacks for specific conditions — PCOS, menopause, sleep, joint health, and more.
Strongest evidence
Supplements with the most solid research behind them
Caf9.5
Caffeine
Likely helpsModerate safety
Blocks adenosine receptors to boost alertness, reaction time, and endurance — one of the most proven ergogenic aids.
Ct9.5
Creatine
Likely helpsHigh safety
Increases phosphocreatine stores for faster ATP regeneration, boosting strength, power output, and cognitive function under stress.
Fe9.0
Iron
Likely helpsModerate safety
Essential mineral for oxygen transport and energy production — critical for those with deficiency, especially women and athletes.
Om39.0
Omega-3
Probably helpsHigh safety
Essential fatty acids critical for brain health, mood regulation, and reducing inflammation throughout the body.
Pro9.0
Probiotics
Likely helpsHigh safety
Live microorganisms where strain selection determines outcome — Lactobacillus and Bifidobacterium strains best studied for gut, immune, and mood.
Wp9.0
Whey Protein
Likely helpsHigh safety
Complete protein with high leucine content that maximizes muscle protein synthesis — most researched protein supplement worldwide.
What notable people actually take
29 documented — never endorsed — regimens, from Attia to Bryan Johnson, with our evidence verdict layered over each. See what they share, or compare any two.
Latest studies
Recently discovered studies across the supplement library
In-depth reports: The State of Supplement Evidence · How supplement trials report their results
Zoledronate or Observation in Maintaining Bone Mineral Density in Patients Who Are Undergoing Surgery to Remove Both Ovaries
· ClinicalTrials.gov
Zoledronic Acid and Combination Chemotherapy in Treating Patients With Newly Diagnosed Metastatic Osteosarcoma
· ClinicalTrials.gov
Safety and Efficacy of Zoledronic Acid in Patients With Breast Cancer With Metastatic Bone Lesions
· ClinicalTrials.gov
Ready to start?
Find out which supplements are worth trying — and which ones you can skip.
Get your plan