Find supplements that actually work
Most supplement sites want to sell you something. SupStack just helps you figure out what's backed by real research — and what's not worth your money.
See how supplements work together
Pick a stack and explore the biological pathways. Click any node to learn more.
How it works
From research to results in four steps
Pick your goals
Sleep, focus, recovery, energy — whatever you're trying to improve.
Build your stack
See how supplements connect to outcomes through biological pathways and build your personalized stack.
Run experiments
Track your personal response with N-of-1 experiments and get a verdict.
Get your personalized supplement report
12 questions. 2 minutes. Science-backed recommendations tailored to your goals, diet, and lifestyle.
Trusted by the community
Join researchers, biohackers, and health-conscious people making evidence-based decisions
500+
Quiz completions
1,200+
Stacks built
8,020+
Peer-reviewed studies analyzed
What makes SupStack different
Research, not marketing
Every supplement is rated based on actual clinical studies — not influencer posts or manufacturer claims.
Sources you can check
Every rating links back to PubMed studies. Don't take our word for it — read the research yourself.
Safety info upfront
Drug interactions, side effects, and who should avoid what — the stuff that's usually buried in fine print.
Continuously validated
Every claim is cross-checked against real studies. Scores and safety ratings get updated as new research comes out.
Condition protocols
25 evidence-based supplement protocols for specific conditions — PCOS, menopause, sleep, joint health, and more.
Strongest evidence
Supplements with the most solid research behind them
Caffeine
Blocks adenosine receptors to boost alertness, reaction time, and endurance — one of the most proven ergogenic aids.
Creatine
Increases phosphocreatine stores for faster ATP regeneration, boosting strength, power output, and cognitive function under stress.
Acetyl-L-Carnitine
Acetylated carnitine that crosses the blood-brain barrier to fuel mitochondrial energy and donate acetyl groups for acetylcholine synthesis.
Aged Garlic Extract
Odorless garlic extract with strong evidence for cardiovascular health, blood pressure, and immune support.
Alpha Lipoic Acid
Universal antioxidant that works in both water and fat, supporting blood sugar control, nerve health, and cellular energy.
Arginine
Primary substrate for nitric oxide production — dilates blood vessels to improve circulation, exercise performance, and cardiovascular health.
Latest Research
Recently discovered studies across the supplement library
Curcumin Supplementation in Critically Ill Patients: A GRADE-Assessed Systematic Review and Meta-Analysis of Randomized Controlled Trial
Arabi SM et al. • Phytotherapy research : PTR (2026)
This meta-analysis demonstrates that curcumin supplementation improves liver function, albumin levels, SOFA scores, and ICU stay duration in critically ill patients, suggesting its potential role in mitigating organ dysfunction in this population.© 2026 John Wiley & Sons Ltd.
Chlorhexidine vs Povidone-Iodine and Incidence of Catheter-Related Infections: A Systematic Review and Meta-Analysis
Drugeon B et al. • JAMA network open (2026)
In this NMA of RCTs, high concentration CHG in isopropyl alcohol was associated with the lowest incidence of CRIs.
Comparative Cleansing Efficacy, Safety, and Tolerability of Bowel Preparation Agents in Pediatric Patients: A Network and Proportional Meta-Analyses of Randomized Controlled Trials
Hsu WT et al. • Digestive diseases and sciences (2026)
Sodium picosulfate with magnesium citrate offers the most favorable balance of efficacy, safety, and tolerability for pediatric colonoscopy preparation.