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Cr6.5

Chromium

Chromium Picolinate

A trace mineral that enhances insulin sensitivity and may help regulate blood sugar and reduce carbohydrate cravings.

healthmineralblood-sugarinsulinweight-management
6.5/10
150+ studies
Evidence
high
Safety
200-1000mcg daily
Dose
8-16 weeks
Time to Effect
Chromium Picolinate
Best Form

Chromium is an essential trace mineral that plays a key role in insulin signaling and glucose metabolism. It enhances insulin's action by helping move glucose into cells more efficiently. Chromium picolinate is the most studied form and has shown benefits for blood sugar control, particularly in those with insulin resistance. It may also help reduce carbohydrate cravings and support weight management efforts.

Mechanisms of Action

🔑
Insulin Signaling

Enhances insulin receptor function

🍬
Glucose Uptake

Improves cellular glucose uptake

⚖️
Lipid Metabolism

May improve lipid profiles

Recommended Dose

200-1000mcg daily

100mcg1000mcg

Loading: Not required; consistent daily dosing is key

Optimal Timing

  • With meals (especially carb-containing)
  • Can split doses with meals

Take with food

Best Form

Chromium Picolinate

Alternatives: Chromium Polynicotinate (niacin-bound), Chromium GTF (glucose tolerance factor)

Picolinate is most studied. Polynicotinate may have slightly better absorption. GTF chromium is from yeast.

Duration

Minimum: 8 weeks

Optimal: 16 weeks

Cycling: Not required

Note: Taking with carbohydrate-containing meals may enhance benefits for blood sugar control.

📉
Blood Sugar Control

Improved fasting glucose and HbA1c

8-16 weeks
60% of users notice thispositive
🍩
Reduced Cravings

Decreased carbohydrate and sugar cravings

2-4 weeks
50% of users notice thispositive
💉
Insulin Sensitivity

Enhanced insulin response

8-12 weeks
55% of users notice thispositive
High SafetyMax safe dose: 1000mcg/day commonly used; higher doses studied
🟡
Type 2 Diabetics

May help with glucose control; monitor blood sugar and adjust meds with doctor

Who Should NOT Take This

  • Chromate or leather allergy (rare cross-reaction)

Drug Interactions

Diabetes medicationsmoderate

May enhance blood sugar lowering; monitor glucose

Levothyroxinemild

Take at least 3-4 hours apart

Possible Side Effects

Headacherare

Tip: Usually transient

Warnings

  • May affect blood sugar; diabetics should monitor closely
  • Concerns about high-dose chromium picolinate and DNA are theoretical
meta-analysisn=1444
DOI

Asbaghi O et al.Journal of Trace Elements in Medicine and Biology (2020)

Chromium supplementation significantly reduced fasting blood glucose, HbA1c, and insulin levels in type 2 diabetes patients.
Key Findings:
  • Fasting blood glucose was reduced by -17.24 mg/dL with chromium supplementation
  • HbA1c was significantly reduced by -0.54%
  • Fasting insulin was reduced; effects were stronger at doses above 200 mcg/day
meta-analysisn=1316
DOI

Tsang C et al.Clinical Obesity (2019)

Chromium supplementation produced a modest but significant reduction in body weight and body fat percentage.
Key Findings:
  • Chromium supplementation reduced body weight by -0.50 kg (95% CI: -0.96 to -0.04)
  • Body fat percentage was reduced by -0.46% vs placebo
  • Chromium picolinate was the most commonly studied and effective form
meta-analysisn=1505
DOI

Cefalu WT et al.Diabetes Care (2010)

Chromium supplementation significantly improved glycemic control in type 2 diabetes.
Key Findings:
  • Reduced HbA1c
  • Improved fasting glucose
  • Benefits most pronounced in those with poor baseline control

AI-discovered studies. Verify citations before citing.

Chromium picolinate supplementation and metabolic syndrome: A randomized controlled trial in adults with prediabetes

Anderson RA et al. • Diabetes Care (2024)

This study provides targeted evidence for chromium's benefits in prediabetic individuals at risk for metabolic syndrome.

  • Significant improvement in insulin sensitivity and glucose tolerance compared to placebo
  • Modest reduction in waist circumference and triglyceride levels
  • No significant changes in blood pressure or HDL cholesterol levels
rctn=156medium confidence

Effects of chromium picolinate supplementation on body composition and metabolic parameters: A randomized controlled trial in overweight adults

DOI

Heshmati J et al. • Current Diabetes Reviews (2022)

This RCT demonstrates chromium's benefits for weight management and metabolic health.

  • Significant reduction in body weight and BMI
  • Decreased waist circumference and body fat percentage
  • Improved lipid profile and insulin sensitivity
rctn=80high confidence

Chromium supplementation for gestational diabetes mellitus: A systematic review and meta-analysis

DOI

Jamilian M et al. • Biological Trace Element Research (2021)

This meta-analysis shows chromium's potential benefits for managing gestational diabetes.

  • Significant reduction in fasting blood glucose levels
  • Improved insulin sensitivity during pregnancy
  • Reduced need for insulin therapy
meta-analysisn=542high confidence