Magnesium (Multiple Forms)
Supports 300+ enzymatic reactions — critical for sleep, stress response, muscle function, and cognitive health.
Magnesium is one of the most important minerals in the body, yet deficiency is extremely common. Different forms target different benefits: glycinate for sleep and anxiety, L-threonate for cognition, malate for energy, and citrate for general use. Most people benefit from 200-400mg daily.
Enhances GABA activity for relaxation and sleep
Regulates muscle contraction and prevents cramps
Modulates HPA axis and reduces cortisol
Required for ATP synthesis and utilization
How Magnesium works — from molecular targets to health outcomes. Click an edge to see supporting research.This visualization is in beta — pathways are being refined and expanded.
200-350mg elemental magnesium daily
Take with food
| Form | Type |
|---|---|
| 💊Depends on goal - see notes | Recommended |
| 💊Glycinate | Alternative |
| 💊L-Threonate | Alternative |
| 💊Malate | Alternative |
| 💊Citrate | Alternative |
| 💊Taurate | Alternative |
GLYCINATE: Best for sleep and anxiety, gentle on stomach. L-THREONATE (Magtein): Best for cognition, crosses blood-brain barrier. MALATE: Best for energy and muscle function. CITRATE: Good all-purpose, may have laxative effect. AVOID OXIDE: Very poor absorption.
Minimum: 2 weeks
Optimal: 4 weeks
Cycling: Not required
Note: Glycinate/threonate best in evening. Malate better in morning. Split doses if taking >200mg to improve absorption and reduce GI effects.
Deeper, more restful sleep
Less anxiety and stress reactivity
Fewer cramps and muscle tension
Some forms may cause loose stools
Generally safe and often recommended; RDA is 350-400mg
Often deficient; may need higher intake
May need more due to sweat losses; 300-400mg recommended
Take 2 hours apart; magnesium reduces antibiotic absorption
Take 2 hours apart; may reduce absorption
Some diuretics increase magnesium loss
Reduced antibiotic effectiveness
Reduced antibiotic effectiveness
Reduced effectiveness for bone health
Treatment failure due to inadequate antibiotic levels
Tip: Use glycinate form; reduce dose; split doses
Tip: Take in evening if this occurs
Magnesium is required to convert vitamin D to active form
Better vitamin D activation and utilization
Both support sleep through different mechanisms
Magnesium for relaxation, glycine for deep sleep
Magnesium supports relaxation while melatonin signals sleep timing
Comprehensive sleep onset and quality support
Magnesium supports serotonin function
Enhanced relaxation and sleep support
Both support GABA and relaxation
Enhanced relaxation and sleep support
Magnesium supports relaxation and sleep
Comprehensive stress and sleep support
Both support energy metabolism
Enhanced energy production and nervous system support
Both support bone and hormonal health
Comprehensive mineral support
Both involved in energy metabolism
Enhanced cellular energy production
Both support muscle relaxation
Enhanced cramp relief
Key electrolyte often deficient
Complete electrolyte support
Magnesium is a GABA receptor co-agonist
Supports GABA function and relaxation
Both support cardiovascular function
Enhanced heart rhythm and blood pressure support
Both support calm and relaxation
Enhanced anxiety relief
Magnesium supports GABA while L-theanine promotes alpha waves
Enhanced relaxation and sleep quality
Magnesium is needed for potassium retention
Proper electrolyte balance
Both support sleep through different mechanisms
Comprehensive sleep support
Both support GABA and relaxation
Enhanced sleep and relaxation support
Both support relaxation and sleep
Enhanced sleep onset and quality
Both support relaxation and sleep
Enhanced calming effect before bed
B6 helps magnesium enter cells
Enhanced magnesium utilization
Magnesium also supports proper calcium metabolism
Comprehensive mineral and calcium regulation support
Both help with PMS symptoms
Comprehensive PMS support
Both often deficient; support sleep and recovery
Comprehensive mineral support for sleep and recovery
Magnesium is required for vitamin D activation and parathyroid hormone function, and competes with calcium for absorption — balance is important.
Balanced calcium-magnesium ratio (2:1) supports bone health, muscle relaxation, and sleep quality
Most MVIs contain only 25-50mg of magnesium — far below the RDA of 310-420mg. Separate magnesium supplementation addresses this common gap.
Complete mineral coverage including adequate magnesium for energy metabolism, sleep, and muscle function
Both support uterine muscle health and relaxation
Complementary support for uterine health
Top studies from 39+ peer-reviewed papers
Makrides M et al. • The Cochrane database of systematic reviews (2014)
“There is not enough high-quality evidence to show that dietary magnesium supplementation during pregnancy is beneficial.”
Duley L et al. • The Cochrane database of systematic reviews (2010)
“Magnesium sulphate more than halves the risk of eclampsia, and probably reduces maternal death.”
Rosanoff A et al. • Nutrients (2024)
“Magnesium reduced systolic BP by 2.81 mmHg and diastolic by 2.05 mmHg compared to placebo.”
Quist-Nelson J et al. • Pregnancy hypertension (2024)
“Early magnesium discontinuation postpartum, usually ≤6 h or none at all, did not significantly increase the rate of postpartum eclampsia, however this study is likely underpowered to demonstrate a difference.”
Behers BJ et al. • Nutrients (2024)
“Both supplements demonstrated greater reductions in SBP for the general population at lower dosages and longer treatment durations.”
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Vitamin D3
9/10Hormone-like vitamin that regulates 1,000+ genes — deficiency is widespread and linked to poor immunity, depression, and bone loss.
Glycine
8.5/10Lowers core body temperature to deepen sleep — 3g before bed reduces daytime fatigue and boosts next-day cognition.
Ashwagandha
7.5/10Reduces cortisol and anxiety while improving sleep quality and physical recovery in stressed adults.
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