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Head-to-head evidence comparison — which supplement is right for you?
Enclomiphene vs Zinc: Zinc has the stronger overall evidence (8.5 vs 4.2/10); they're alternatives for fertility support — the best pick depends on your goals. Take the 60-second quiz for a pick tailored to your goals.
Zinc wins 3 of 3 categories. Both are solid choices — the best pick depends on your specific goals.
Verdict
Mostly mechanism / observational
Top outcomes
Verdict
Likely helps
21 of 26 studies with measurable effects showed benefit.
Top outcomes
Investigational / off-label — no FDA-approved dose exists. Trials studied oral enclomiphene citrate at 6.25-25 mg once daily (12.5 mg and 25 mg were the Phase-3 doses). Compounded enclomiphene is used off-label under a clinician at similar doses, but quality and content are not regulated.
any
Oral enclomiphene citrate (compounded; investigational — never marketed as an approved drug)
15-30mg daily
With meals
Zinc picolinate or zinc citrate
Weeks to a few months
Within 3-6 months
N/A
N/A
2-4 weeks
2-4 weeks
4-8 weeks
Immediate
Oral enclomiphene citrate raises testosterone and preserves sperm counts in obese hypogonadal men, unlike topical testosterone: restoration instead of replacement.
BJU Int (2016) · Rct
Two parallel randomized, double-blind, double-dummy, placebo-controlled, multicentre Phase-3 trials (ZA-304/ZA-305) of 12.5 mg and 25 mg enclomiphene vs testosterone gel (AndroGel 1.62%) in overweight men 18-60 with secondary hypogonadism
Enclomiphene citrate stimulates testosterone production while preventing oligospermia: a randomized phase II clinical trial comparing topical testosterone.
Fertil Steril (2014) · Rct
Phase-2 randomized trial of oral enclomiphene citrate vs 1% topical testosterone gel in men with secondary hypogonadism (NCT01270841)
Oral enclomiphene citrate stimulates the endogenous production of testosterone and sperm counts in men with low testosterone: comparison with testosterone gel.
J Sex Med (2013) · Open label · n=12
Proof-of-principle randomized, open-label, active-control, two-center Phase-2B study in 12 men with secondary hypogonadism previously on topical testosterone
Efficacy of Zinc Supplementation in the Management of Primary Dysmenorrhea: A Systematic Review and Meta-Analysis
Nutrients (2024) · Meta analysis · n=739
Zinc supplementation significantly reduced pain severity compared to placebo (Hedges's g = -1.541; 95% CI: -2.268 to -0.814; p < 0.001), representing a clinically meaningful reduction in pain.
Effects of Daily Zinc Alone or in Combination with Other Nutrient Supplements on the Risk of Malaria Parasitaemia: A Systematic Review and Meta-Analysis of Randomised Controlled Trials
Nutrients (2023) · Meta analysis · n=1339
The effect sizes, represented as risk ratios (RRs) with 95% confidence intervals (CIs), were standardised by transforming them into log RRs and then pooling them using a fixed-effects or random-effects model depending on the heterogeneity across studies.
Prevalence of Zinc Deficiency in Inflammatory Bowel Disease: A Systematic Review and Meta-Analysis
Nutrients (2022) · Meta analysis · n=806
Pooled analyses by the IBD subgroup showed a total population of 1677 with CD, for an overall mean zinc deficiency prevalence of 54% and 95% confidence intervals (CI) ranging from 0.51 to 0.56, versus 41% (95%CI 0.38-0.45) in the UC population (n = 806).
Based on meta-analyses showing reduced respiratory tract infections and improved immune markers (CD3/CD4). Effects primarily in deficient individuals. Take with food to reduce nausea risk.
AI-estimated from published studies. Interpret as directional guidance.
Zinc has a higher evidence score (8.5/10 vs 4.2/10) and wins in 3 of 3 categories.
For fertility support, Zinc has a higher relevance score (85 vs 60).
No known interactions between Enclomiphene and Zinc have been documented in our database. However, always consult a healthcare provider before combining supplements.
AREDS2 works for diagnosed AMD; lutein/screen-strain claims are weaker. Who actually benefits.
The popular one (saw palmetto) mostly fails in rigorous trials; beta-sitosterol is the better bet.
Selenium helps; iodine can WORSEN Hashimoto’s. The honest take on "thyroid support".
CoQ10, zinc, selenium, carnitine modestly help sperm parameters — but live-birth evidence is weak.
The right pick depends on your goals. Answer a few quick questions for a personalised recommendation — or dig into the full evidence on each.