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Cognitive supplements span four very different goals — sharpening focus right now, building memory over months, protecting the brain over decades, and managing mood and anxiety in the meantime. Different mechanisms, different evidence bases, different time horizons.
Top picks: L-Theanine, Probiotics, and Saffron — full evidence and dosage details below.
Pick the outcome you actually care about for the most relevant supplements.
Ranked by how many of this area's outcomes each supplement shows pooled benefit on. Click a row for the per-outcome breakdown.
Pre-built, evidence-based supplement combinations targeting goals in this area.
Supplements researched for supporting the body's stress response, promoting calm, and supporting healthy cortisol levels.
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Supplements researched for supporting focus, mental clarity, and cognitive performance.
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Supplements researched for supporting emotional well-being, neurotransmitter balance, and positive mood.
Neuroprotection in the age of emerging infections: The untapped power of medicinal mushrooms
2026 · Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · systematic-review
Oxiracetam and physical activity in preventing cognitive decline after stroke: A multicenter, randomized controlled trial
2026 · European stroke journal · rct
Nattokinase supplementation for cognitive enhancement in asymptomatic intracranial/carotid stenosis: A randomized controlled trial
2026 · Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association · rct
A randomised controlled study to investigate the cognitive, mood, metabolic and anti-inflammatory effects of acute oyster mushroom intervention in healthy older adults
2026 · Food & function · rct
Targeting PTSD with ultramicronized palmitoylethanolamide: Results from a randomized trial integrating pharmacotherapy and cognitive behavioral therapy
2026 · Journal of psychiatric research · rct
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