Supplements for Vitality & Longevity

Activates AMPK to regulate blood sugar, improve insulin sensitivity, and support lipid metabolism — comparable to metformin in some trials.

Odorless garlic extract with strong evidence for cardiovascular health, blood pressure, and immune support.

NAD+ precursor that raises HDL, lowers LDL and triglycerides, and fuels cellular energy metabolism at therapeutic doses.

Turmeric's active compound that modulates NF-kB inflammatory pathways — supports mood, joint health, and post-exercise recovery.

Gel-forming soluble fiber that lowers LDL cholesterol, regulates blood sugar, and promotes digestive regularity.

Enzyme from Japanese fermented soybeans that supports healthy blood flow and may help break down fibrin.

Fat-soluble form of vitamin B1 with superior absorption that protects against glycation and supports nerve health.

A polyphenol-rich fruit with consistent antioxidant and anti-inflammatory effects (and possible blood-pressure/vascular benefit) — but meta-analysis shows no meaningful effect on blood lipids.

An antioxidant berry rich in zeaxanthin. The cleanest signal is modest improvements in lipid/cardiovascular markers; eye and anti-ageing claims are mostly mechanistic, on a small evidence base.

Flavanol-rich extract from cocoa beans, standardized for epicatechin. The largest trial (COSMOS, 21,442 adults) MISSED its primary cardiovascular endpoint but cut CVD death by 27% as a secondary outcome. Meta-analyses show a small (~2 mmHg) blood-pressure drop and improved endothelial function; cognitive benefit in the same trial was null.

An omega-7-rich berry/oil with emerging RCT evidence for dry eye, mucosal/skin health, and lipids in people with dyslipidemia — but effects are modest, often subgroup-dependent, and trials are small.

A decades-old non-dihydropyridine calcium-channel blocker for hypertension, angina, and arrhythmia, being repurposed to PRESERVE pancreatic beta-cell function in new-onset type-1 diabetes. Two randomized trials (adults — Nature Medicine 2018; children/adolescents — JAMA 2023, CLVer) show it partially preserves C-peptide. The benefit is partial and adjunctive — not a cure, and it wanes after stopping. A prescription drug, not a supplement.