Known stacks

A physician-led healthspan regimen built around aggressive ApoB/lipid lowering, cyclical rapamycin, high-dose omega-3, and a sleep/recovery layer — reconstructed from his public statements. Documented for reference, not endorsed.

17 items · as of 2026-06

The Harvard geneticist’s widely-cited NAD+/sirtuin-centric regimen — NMN, resveratrol and a metabolic agent — reconstructed from his book, podcast and interviews. He resists the "fixed protocol" framing; documented as reported, not endorsed.

11 items · as of 2026-06

The most-publicized longevity protocol — a 100+ item daily regimen; this documents ~20 of its most-notable compounds from the official protocol page. Documented, not endorsed.

20 items · as of 2026-01

The neuroscientist-podcaster’s reported personal stack — a sleep "cocktail," cycled cognition aids, and a testosterone-support pair (tongkat ali + fadogia). Documented as reported, not endorsed; several items he frames as experimental or cycled.

16 items · as of 2026-06

The FoundMyFitness scientist’s evidence-first, biomarker-titrated stack — high-dose omega-3 and vitamin D to lab targets, plus sulforaphane and a mitochondrial layer. Documented as reported, not endorsed; she titrates to bloodwork rather than fixed doses.

14 items · as of 2026-06

A recognizable testosterone-replacement optimization pattern — base TRT plus the adjuncts men commonly add for fertility, estrogen control and erectile function. An archetype, not any individual’s protocol; all prescription/gated, requires clinician supervision, documented not endorsed.

7 items · as of 2026-06

The deliberately conservative, all-evidence-backed starter stack — the "all-green" counterpoint to the maximalist regimens. Every item is a real, recommendable supplement with genuine human evidence; nothing gated or grey-market.

7 items · as of 2026-06

Harm-reduction documentation of what a typical first SARM cycle and its "on-cycle support / post-cycle therapy" actually contain — NOT a protocol or endorsement. SARMs are unapproved, gated research compounds with real risks (HPTA suppression, adverse lipids, liver injury) and rampant product mislabeling. The evidence layer here is mostly grey-market with no human approval.

7 items · as of 2026-06

The podcaster’s reported routine — well-established in fact but poorly documented in dose. Only his vitamin D figure is firmly his own; many numbers circulating online are mis-attributed (the NMN/zinc/quercetin doses are guests’ or Sinclair’s). COI: he holds Onnit equity and AG1 sponsors the show. Documented, not endorsed.

9 items · as of 2026-06

The 10X Health figure’s MTHFR/methylation-centric routine — methylated B-vitamins, D3/K2, TMG and his signature methylene blue. SEVERE COI: nearly every item is a 10X Health / Ultimate Human product he sells, and no primary dose sheet exists. Documented as a seller’s self-report, not endorsed.

8 items · as of 2026-06

The Bulletproof founder’s reported regimen — he claims 100+ pills/day and withholds the full list. SEVERE COI: he sells branded versions of most items (Suppgrade Labs, Bulletproof, Danger Coffee, Upgrade Labs). Documented by underlying compound, not endorsed; notable for what he has publicly stopped.

16 items · as of 2026-06

The biohacker’s sprawling daily stack — supplements, peptides and experimental longevity compounds. COI: a large share is his own Kion brand plus paid affiliates. Documented by underlying compound, not endorsed; notable for rejecting branded NMN/NR in favor of niacinamide.

18 items · as of 2026-06

The most-followed independent TRT/PED harm-reduction educator (not a doctor; co-founded Marek Health). His own documented regimen centers on low, daily TRT and a topical anti-androgen hair protocol; he covers HCG/SERMs/AIs educationally. Documented, not endorsed; TRT figures date to a ~2020 writeup.

7 items · as of 2026-06

The anti-hype scientist’s short, evidence-backed list — his line is "95% of supplements are junk." A named all-green counterpoint; he publicly dismisses turkesterone, NMN/resveratrol and premium creatine forms. COI: sells creatine/whey/caffeine via Outwork. Documented, not endorsed.

6 items · as of 2026-06

The functional-medicine figure’s reported regimen. SEVERE COI: his most-cited "personal stack" is literally a 13-product bundle he sells, and he co-founded Function Health (the test-and-sell loop). Doses are product-label, not spoken figures. Documented by underlying compound, not endorsed. He does not take metformin or rapamycin.

15 items · as of 2026-06

The biogerontologist’s deliberately short list — he stresses exercise/sleep/nutrition deliver the vast majority of benefit and supplements only "incremental" gains, dosing only to correct a measured deficiency. He takes NO NAD precursor. Note: the widely-circulated "stopped rapamycin after side effects" story is Bryan Johnson’s — Kaeberlein continues cycling it. Documented, not endorsed.

9 items · as of 2026-06

The TAME-trial metformin researcher’s reported personal regimen is essentially just metformin — taken for his own prediabetes — plus lifestyle. He is publicly skeptical of supplements, would reach for an approved drug first, and explicitly DECLINES vitamin D ("I have the lowest vitamin D in the world and I’m not taking it"). The conservatism is the story; he does not recommend metformin for healthy people outside a trial.

2 items · as of 2026-06

The TB12 method is overwhelmingly anti-inflammatory diet + hydration + pliability training — the actual supplement core is small. COI: he co-founded TB12 and the items are his own product line. Documented by underlying compound, not endorsed; doses are product-label, never his own figures.

8 items · as of 2026-06

The prototypical n=1 self-experimenter: a nightly sleep stack, a daily performance/“nutritional insurance” layer, and a few cycled extras — reconstructed from his own recent statements. COI: much of his current lineup is product he sponsors or invests in (Momentous, Seed, AG1, LMNT). Documented as reported (he names forms more than doses), not endorsed.

13 items · as of 2026-06

The longevity scientist who takes almost nothing: a multivitamin and an algal-oil omega-3 every few days (deliberately not daily, to avoid over-supplementing), with plant protein only when food runs short. The real intervention is the diet and his periodic Fasting-Mimicking Diet. COI: he founded L-Nutra / the ProLon FMD product line. Documented, not endorsed.

3 items · as of 2026-06

An OB/GYN’s documented foundation for menopausal and midlife women — omega-3, vitamin D3+K2, creatine, fiber, magnesium and collagen — with hormone therapy framed as her clinical recommendation, not a supplement. COI: she founded and sells The ’Pause Life supplement line, so most items map to her own products. Documented, not endorsed.

13 items · as of 2026-06

A “muscle-centric medicine” foundation built around adequate protein (she targets ~1 g per lb ideal bodyweight) plus a short, evidence-led supplement layer — creatine, omega-3, vitamin D and a few muscle/mitochondrial extras. COI: she partners with supplement brands and runs a shop. Documented as reported, not endorsed.

8 items · as of 2026-06

A maximalist “address every hallmark of aging” regimen — by his own account ~75 pills a day, adjusted off quarterly bloodwork — spanning aggressive lipid lowering, rapamycin, TRT, NAD precursors and a broad antioxidant layer. The notable items are below. COI: he co-founded Lifeforce / Fountain Life (diagnostics + supplements). Documented as reported, not endorsed.

22 items · as of 2026-06

An evidence-first exercise physiologist’s approach: a short foundational layer (creatine, omega-3, vitamin D, magnesium), then goal-specific performance and recovery additions, all individualized and titrated to bloodwork. Documented as reported, not endorsed.

11 items · as of 2026-06

A female-longevity biohacker’s protocol — she reports ~30–35 supplements a day, amended off testing — built on omega-3, vitamin D3+K2, creatine, colostrum and NAD precursors, with hormone-support extras. The publicly named items are below. COI: she has brand partnerships / affiliate relationships. Documented as reported, not endorsed.

15 items · as of 2026-06

The evidence-based-vegan counterpoint: get nutrients from whole plant foods (his “Daily Dozen”) and supplement only the genuinely hard-to-get ones — B12, vitamin D and algae-derived omega-3. A deliberately tiny, low-COI regimen. Documented as reported, not endorsed.

4 items · as of 2026-06

“Women are not small men”: an exercise physiologist’s female-athlete approach — protein and creatine to hit higher targets, electrolytes around training, and the deficiencies women most often run into (iron, vitamin D, omega-3). Third-party-tested products emphasized. Documented as reported, not endorsed.

6 items · as of 2026-06

A plant-based ultra-endurance athlete who deliberately keeps it simple: whole-food vegan diet plus the three supplements that are genuinely hard to get plant-based — B12, vitamin D and algae omega-3 — taken to bloodwork. COI: he sells a plant-based recovery/protein line. Documented as reported, not endorsed.

3 items · as of 2026-06

The most-asked sleep expert takes essentially nothing for sleep and is openly skeptical of sleep supplements — the real levers are behavioral (light, temperature, consistency, caffeine/alcohol timing). Below are the two most-asked-about supplements with his verdict. Documented as reported, not endorsed.

2 items · as of 2026-06