Compare Supplements

Side-by-side comparison of 1 supplements

Ae22.5

17-Alpha-Estradiol

Limited safety

Evidence

Evidence ScoreNot scored

Studies: 4

Meta-analyses: 0

Dosage & timing

Dosage:

No validated human dose. The mouse studies delivered it in food at defined ppm; grey-market oral dosing for longevity is anecdotal and unsupported by any human data.

Best Time:

Any time

Can take on empty stomach

Form:

None established (research compound)

What you'll notice

⏳ Lifespan extension (male mice)positive

Unknown in humans

📉 Metabolic improvement (animal)positive

Unknown in humans

ℹ️ No human dataneutral

N/A

Safety

Limited safety

Contraindications:

Pregnancy / breastfeeding
Women (sex-specific harms; promotes ovarian aging in models)
Hormone-sensitive conditions

Side Effects:

Unknown human hormonal effects

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