What's New

Effect of Probiotic and Synbiotic Oral Supplementation in Autoimmune Diseases: An Updated Systematic Review and Meta-Analysis of Randomized Controlled Trials

Further studies with longer follow-up durations are needed to confirm these findings and explore the long-term benefits of probiotics in this population.

Heterogeneity of Treatment Effects of Glucagon-Like Peptide-1 Receptor Agonists for Weight Loss in Adults: A Systematic Review and Meta-Analysis

In this systematic review and meta-analysis, GLP-1 RAs produced greater weight loss among women than men; however, their efficacy was consistent across other important subpopulations.

Calcium, vitamin D, or combined supplementation to prevent fractures and falls: systematic review and meta-analysis

Based on absolute risk reductions and thresholds considered clinically meaningful, this review found little to no benefits from use of calcium, vitamin D, or combined supplementation on the prevention of fractures and falls.

Explore the Optimal Treatment Regimen Across Combinations of Variate Protein Sources and Exercise Modalities and Its Associated Factors in Older Adults: A Network Meta-Analysis and Meta-Regression of Randomized Controlled Trials

The present NMA results indicate that whey protein incorporated with resistance training is the optimal program to help combat sarcopenia in older adults.

Comparative Effects of Dietary Protein, Creatine, and Omega-3 Supplementation on Muscle Strength, Endurance, and Recovery in Trained Athletes: A Systematic Review and Network Meta-Analysis

These findings reveal an outcome-specific efficacy pattern supporting targeted supplementation strategies aligned with primary training objectives in athletic populations.

Comparative Effectiveness of Pharmacological and Non-Pharmacological Interventions for Nausea and Vomiting in Pregnancy: A Systematic Review and Network Meta-Analysis

Conclusions: This study indicates that both pharmacological (vitamin B6, metoclopramide, dimenhydrinate) and non-pharmacological (ginger, quince, acupressure, acupuncture) interventions might be effective in reducing symptoms of nausea and vomiting in pregnancy.

Long-term effects of weight-reducing drugs in people with hypertension

There have been multiple developments in the domain of medications for long-term weight reduction in recent years.

Circulating Lycopene and β-Carotene Levels Are Inversely Associated with Carotid Intima-Media Thickness: A Systematic Review and Meta-Analysis

The effect appears more pronounced in men, highlighting potential sex-specific differences in carotenoid metabolism and cardiovascular risk modulation.

Oral or parenteral iron supplementation to reduce deferral, iron deficiency and/or anaemia in blood donors

Iron supplementation may lead to improved blood indices and iron stores, but we are uncertain about the effect due to heterogeneity in the population and different methods and doses of iron supplementation.

Association Between Levels of Magnesium and Diabetic Retinopathy in Diabetic Patients with Type 2 Diabetes Mellitus: An Updated Systematic Review and Meta-Analysis

This systematic review and meta-analysis conclude that magnesium levels are significantly lower in patients with diabetic retinopathy than in diabetic controls without retinopathy.

Differential Acute Kidney Injury Profiles of GLP-1RAs and SGLT2is: A Network Meta-Analysis

Further prospective trials are needed to clarify causal mechanisms and inform clinical decision-making.

Dose-Response Effect of Oral Caffeine Use on Aerobic Exercise Performance: A Systematic Review and Meta-Analysis

Notably, the use of moderate caffeine doses (4-6 mg·kg -1 ) appears to produce a more consistent ergogenic effect.

Creatine monohydrate for lean mass, strength, and bone density in postmenopausal women: a systematic review and meta-analysis

In postmenopausal women, creatine, particularly ≥ 5 g·day⁻¹ with RT, yields small but meaningful gains in lean mass and strength without evidence of harm.

Complex Effects of B-Vitamin Combinations on Cardiovascular Diseases: A Systematic Review and Meta-Analysis of Randomized Controlled Trials over Three Decades

Overall, B-vitamin combinations do not confer consistent benefit for major cardiovascular outcomes but may reduce stroke and MACE in selected primary prevention populations, suggesting that baseline cardiovascular risk and regional folic acid fortification modify treatment effects and should guide future trial design and clinical use.

Hand-foot syndrome prevention: pharmacological interventions-systematic review and network meta-analysis

Prospero registration number CRD42025643635.

Lacto-ovo-vegetarian and vegan diets in children and adolescents: a systematic review and meta-analysis of nutritional and health outcomes

These findings underscore the need for careful dietary planning and supplementation in lacto-ovo-vegetarian and vegan children.

Preventing Hand-Foot Syndrome in Patients With Cancer: A Systematic Review and Network Meta-Analysis

In this systematic review and network meta-analysis, diclofenac and silymarin were the most effective preventive strategies for HFS, with silymarin requiring confirmation in a larger randomized trial.

Pharmacological treatments for Friedreich ataxia

In this updated Cochrane systematic review, meta-analysis of results on the ataxia rating scale showed that pharmacological treatments probably make little or no difference compared with placebo after 12 months of treatment.

The Effects of Seaweed and Microalgae Supplementation on Exercise Performance and Recovery: A Systematic Review and Meta-Analysis

High-quality, multi-center RCTs incorporating mechanistic endpoints are needed to clarify optimal application and to develop athlete-specific recommendations.

Circulating Short-Chain Fatty Acid Levels in Chronic Kidney Disease: A Systematic Review and Meta-Analysis

CKD is associated with a profound systemic reduction in acetate and propionate, supporting the model of a compromised gut-kidney axis based on converging evidence.

Nutritional Supplementation Combined with Exercise for Musculoskeletal Health in Women: A Systematic Review and Meta-Analysis Evaluating Proteins, Amino Acids, and Creatine across Reproductive Stages

Current evidence does not support robust additive effects of nutritional supplementation on muscle mass or bone health when combined with exercise in women across reproductive stages.

Cutting Through the Clot: Rethinking Venous Thromboembolism Prophylaxis in Plastic Surgery with Aspirin, Direct Oral Anticoagulants, and Low Molecular Weight Heparin.

Aspirin and other nonsteroidal anti-inflammatory drugs (NSAIDs) for preventing colorectal cancer and colorectal adenoma in the general population.

Continued versus Discontinued Oxytocin in the Active Phase of Induced Labor in Term Pregnancies: An Updated Systematic Review and Meta-Analysis of Randomized Controlled Trials.

Comparative effectiveness of probiotics, prebiotics, synbiotics, and postbiotics in preventing dental caries: a meta-analysis from an oral microbiota modulation perspective.

Comparative efficacy and safety of different tranexamic acid administration in spine surgery: a network meta-analysis.

Antiplatelet dilemma: Clopidogrel or aspirin for long-term cardiovascular protection after dual antiplatelet therapy following PCI.

Antithrombotic agents in the treatment of severe mental illness: A systematic review and meta-analysis of randomized controlled trials.

A systematic study of molecular diagnosis, treatment, and prognosis in infant-type hemispheric glioma: An individual patient data meta-analysis of 164 patients.

Early aspirin withdrawal versus dual antiplatelet therapy in high-risk patients after percutaneous coronary intervention: Meta-analysis of randomized trials.

Colchicine for the Secondary Prevention of Cardiovascular Diseases: A Cumulative-Dose Meta-analysis of Randomized Controlled Trials including 31,397 Subjects Worldwide.

Clopidogrel versus aspirin monotherapy following dual antiplatelet therapy after percutaneous coronary intervention: an updated meta-analysis of 162,829 patients.

Colchicine in acute coronary syndromes: a systematic review and meta-analysis of randomised controlled trials.

Circulating Short-Chain Fatty Acid (SCFA) profiles as a biomarker of gut-brain axis dysfunction: A meta-analysis for the SCFA signature in major depression.

Clomiphene citrate versus testosterone replacement therapy in male hypogonadism: a systematic review of literature and meta-analysis.

Combination pitavastatin-ezetimibe therapy for hypercholesterolemia and mixed dyslipidemia: a systematic review and meta-analysis.

Affordable Excellence: A Meta-Analysis on the Efficacy of Topical Tranexamic Acid in Reducing Blood Loss in Thoracolumbar Spinal Surgery.

Can probiotics reduce chemotherapy-induced complications in leukemia patients? A systematic review and meta-analysis of randomized controlled trials.

Benefits of Nanocurcumin on Mortality in Patients with COVID-19: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.

Beneficial Impacts of pre- and Postoperative Probiotics/Synbiotics Supplementation in Patients Undergoing Gastrointestinal Surgeries: An Umbrella Meta-Analysis.