What's New

Optimal dose window, formulation efficacy, and molecular mechanisms of curcumin in MASLD animal models: A systematic review and three-level meta-analysis.

Pathogenesis and therapeutic potential of traditional Chinese medicine intervention in hypertension combined with insomnia

TCM exhibits remarkable therapeutic efficacy in the treatment of HTN-Ins through multi-target, multi-pathway, multi-level, and individualized strategies, thereby demonstrating substantial therapeutic potential.

Oral or parenteral iron supplementation to reduce deferral, iron deficiency and/or anaemia in blood donors

Iron supplementation may lead to improved blood indices and iron stores, but we are uncertain about the effect due to heterogeneity in the population and different methods and doses of iron supplementation.

Circulating Short-Chain Fatty Acid Levels in Chronic Kidney Disease: A Systematic Review and Meta-Analysis

CKD is associated with a profound systemic reduction in acetate and propionate, supporting the model of a compromised gut-kidney axis based on converging evidence.

Association Between Levels of Magnesium and Diabetic Retinopathy in Diabetic Patients with Type 2 Diabetes Mellitus: An Updated Systematic Review and Meta-Analysis

This systematic review and meta-analysis conclude that magnesium levels are significantly lower in patients with diabetic retinopathy than in diabetic controls without retinopathy.

Nutritional Supplementation Combined with Exercise for Musculoskeletal Health in Women: A Systematic Review and Meta-Analysis Evaluating Proteins, Amino Acids, and Creatine across Reproductive Stages

Current evidence does not support robust additive effects of nutritional supplementation on muscle mass or bone health when combined with exercise in women across reproductive stages.

Hand-foot syndrome prevention: pharmacological interventions-systematic review and network meta-analysis

Long-term effects of weight-reducing drugs in people with hypertension

There have been multiple developments in the domain of medications for long-term weight reduction in recent years.

Heterogeneity of Treatment Effects of Glucagon-Like Peptide-1 Receptor Agonists for Weight Loss in Adults: A Systematic Review and Meta-Analysis

In this systematic review and meta-analysis, GLP-1 RAs produced greater weight loss among women than men; however, their efficacy was consistent across other important subpopulations.

Circulating Lycopene and β-Carotene Levels Are Inversely Associated with Carotid Intima-Media Thickness: A Systematic Review and Meta-Analysis

The effect appears more pronounced in men, highlighting potential sex-specific differences in carotenoid metabolism and cardiovascular risk modulation.

Comparative Effects of Dietary Protein, Creatine, and Omega-3 Supplementation on Muscle Strength, Endurance, and Recovery in Trained Athletes: A Systematic Review and Network Meta-Analysis

These findings reveal an outcome-specific efficacy pattern supporting targeted supplementation strategies aligned with primary training objectives in athletic populations.

Complex Effects of B-Vitamin Combinations on Cardiovascular Diseases: A Systematic Review and Meta-Analysis of Randomized Controlled Trials over Three Decades

Overall, B-vitamin combinations do not confer consistent benefit for major cardiovascular outcomes but may reduce stroke and MACE in selected primary prevention populations, suggesting that baseline cardiovascular risk and regional folic acid fortification modify treatment effects and should guide future trial design and clinical use.

Calcium, vitamin D, or combined supplementation to prevent fractures and falls: systematic review and meta-analysis

Based on absolute risk reductions and thresholds considered clinically meaningful, this review found little to no benefits from use of calcium, vitamin D, or combined supplementation on the prevention of fractures and falls.

Differential Acute Kidney Injury Profiles of GLP-1RAs and SGLT2is: A Network Meta-Analysis

Further prospective trials are needed to clarify causal mechanisms and inform clinical decision-making.

Lacto-ovo-vegetarian and vegan diets in children and adolescents: a systematic review and meta-analysis of nutritional and health outcomes

These findings underscore the need for careful dietary planning and supplementation in lacto-ovo-vegetarian and vegan children.

Comparative Effectiveness of Pharmacological and Non-Pharmacological Interventions for Nausea and Vomiting in Pregnancy: A Systematic Review and Network Meta-Analysis

Conclusions: This study indicates that both pharmacological (vitamin B6, metoclopramide, dimenhydrinate) and non-pharmacological (ginger, quince, acupressure, acupuncture) interventions might be effective in reducing symptoms of nausea and vomiting in pregnancy.

Preventing Hand-Foot Syndrome in Patients With Cancer: A Systematic Review and Network Meta-Analysis

In this systematic review and network meta-analysis, diclofenac and silymarin were the most effective preventive strategies for HFS, with silymarin requiring confirmation in a larger randomized trial.

The Effects of Seaweed and Microalgae Supplementation on Exercise Performance and Recovery: A Systematic Review and Meta-Analysis

High-quality, multi-center RCTs incorporating mechanistic endpoints are needed to clarify optimal application and to develop athlete-specific recommendations.

Effect of Probiotic and Synbiotic Oral Supplementation in Autoimmune Diseases: An Updated Systematic Review and Meta-Analysis of Randomized Controlled Trials

Further studies with longer follow-up durations are needed to confirm these findings and explore the long-term benefits of probiotics in this population.

Dose-Response Effect of Oral Caffeine Use on Aerobic Exercise Performance: A Systematic Review and Meta-Analysis

Notably, the use of moderate caffeine doses (4-6 mg·kg -1 ) appears to produce a more consistent ergogenic effect.

Creatine monohydrate for lean mass, strength, and bone density in postmenopausal women: a systematic review and meta-analysis

In postmenopausal women, creatine, particularly ≥ 5 g·day⁻¹ with RT, yields small but meaningful gains in lean mass and strength without evidence of harm.

Pharmacological treatments for Friedreich ataxia

In this updated Cochrane systematic review, meta-analysis of results on the ataxia rating scale showed that pharmacological treatments probably make little or no difference compared with placebo after 12 months of treatment.

Explore the Optimal Treatment Regimen Across Combinations of Variate Protein Sources and Exercise Modalities and Its Associated Factors in Older Adults: A Network Meta-Analysis and Meta-Regression of Randomized Controlled Trials

The present NMA results indicate that whey protein incorporated with resistance training is the optimal program to help combat sarcopenia in older adults.

Metformin in High Metabolic Risk Pregnancies - A Patient-Level Meta-Analysis

Conclusions In this IPD meta-analysis, metformin was not associated with a reduction in GDM, but was associated with an increase in gestational age at delivery.

Evaluating Reduced Use and Abstinence as Outcomes in Pharmacotherapy Trials for Stimulant Use Disorder: A Meta-Analysis of 12 Randomized Controlled Trials

The results suggest that reductions in stimulant use may serve as meaningful efficacy signals that could be underestimated when relying solely on stringent outcomes, such as abstinence.

Efficacy and mechanisms of Xiangsha Liujunzi Decoction for gastroesophageal reflux disease: A study integrating meta-analysis, network pharmacology and molecular docking

XSLJZD may improve RE symptoms as an adjunctive therapy, but the evidence is low in certainty.

Caffeine and IBD Risk: A Meta-Analysis

The relationship between caffeine intake and IBD risk varies by region, age, caffeine source, smoking, and education level.

Ginkgo biloba for cognitive impairment and dementia

In people with dementia, there may be small to moderate benefits at six months for global status, cognition, and ADLs.

Research Review: Omega-3 supplementation to reduce antisocial behavior - a systematic review and meta-analysis of randomized controlled trials.

Raspberry polysaccharide extraction, purification, structural characterization, and biological activity research progress: A review

Consequently, elucidating the intricate process-structure-activity relationship is paramount for their effective utilization.

Diagnostic accuracy of transvaginal ultrasound-measured endometrial thickness and serum hCG levels in detecting retained products of conception: a systematic review and meta-analysis.

The Efficacy of Gut Microbiome-Modulating Therapies on Liver Cirrhosis: A Systematic Review and Network Meta-Analysis.

Colchicine in cardiovascular disease: A systematic review and meta-analysis of randomized controlled trials.

Effect of polyunsaturated fatty acids supplementation on nutritional status in patients with pancreatic cancer: a systematic review and meta-analysis.

Efficacy and safety of intravenous ferric carboxymaltose versus oral iron in pregnant women with anemia: a systematic review and meta-analysis.

Teriparatide Therapy in Children with Hypoparathyroidism: A Systematic Review and Meta-Analysis.

Assessing current applications of tranexamic acid in reconstructive microsurgery and future direction: An 11-year meta-analysis.

SGLT2 inhibitors and secondary polycythemia: a systematic review and meta-analysis of hematologic effects in patients with type 2 diabetes.

SGLT2 Inhibitors and Kidney Outcomes by Glomerular Filtration Rate and Albuminuria: A Meta-Analysis.

Beyond insulin therapy: Comparing relative benefits of adding SGLT2 versus DPP4 inhibitors in poorly controlled type 2 diabetic patients: A systematic review and meta-analysis.