What's New

Optimal dose window, formulation efficacy, and molecular mechanisms of curcumin in MASLD animal models: A systematic review and three-level meta-analysis.

Impact of lamiaceae plants on anthropometric indices in patients with metabolic syndrome: A systematic review and meta-analysis of randomized clinical trials

Lamiaceae supplementation is associated with modest reductions in size-based and central adiposity indices (BMI, WC, WHR) in adults with metabolic syndrome; exploratory subgroup analyses suggested potential signals for Salvia and Zataria, though based on limited trials.

Harnessing natural herbaceous plants against ferroptosis: Implications for managing polycystic ovary syndrome

Traditional Chinese compound formulations hold significant promise for developing drugs targeting PCOS.

Pathogenesis and therapeutic potential of traditional Chinese medicine intervention in hypertension combined with insomnia

TCM exhibits remarkable therapeutic efficacy in the treatment of HTN-Ins through multi-target, multi-pathway, multi-level, and individualized strategies, thereby demonstrating substantial therapeutic potential.

Oral or parenteral iron supplementation to reduce deferral, iron deficiency and/or anaemia in blood donors

Iron supplementation may lead to improved blood indices and iron stores, but we are uncertain about the effect due to heterogeneity in the population and different methods and doses of iron supplementation.

Circulating Short-Chain Fatty Acid Levels in Chronic Kidney Disease: A Systematic Review and Meta-Analysis

CKD is associated with a profound systemic reduction in acetate and propionate, supporting the model of a compromised gut-kidney axis based on converging evidence.

Association Between Levels of Magnesium and Diabetic Retinopathy in Diabetic Patients with Type 2 Diabetes Mellitus: An Updated Systematic Review and Meta-Analysis

This systematic review and meta-analysis conclude that magnesium levels are significantly lower in patients with diabetic retinopathy than in diabetic controls without retinopathy.

Does intranasal oxytocin reduce symptoms of mental disorders? A meta-analysis of clinical trials

However, trial methods seldom aligned with optimal protocols.

Comparative efficacy and acceptability of anxiolytic drugs for the treatment of anxiety disorders: a systematic review and network meta-analysis

This network meta-analysis provides a unique comparison of the efficacy and acceptability of anxiolytics.

Nutritional Supplementation Combined with Exercise for Musculoskeletal Health in Women: A Systematic Review and Meta-Analysis Evaluating Proteins, Amino Acids, and Creatine across Reproductive Stages

Current evidence does not support robust additive effects of nutritional supplementation on muscle mass or bone health when combined with exercise in women across reproductive stages.

Long-term effects of weight-reducing drugs in people with hypertension

There have been multiple developments in the domain of medications for long-term weight reduction in recent years.

Heterogeneity of Treatment Effects of Glucagon-Like Peptide-1 Receptor Agonists for Weight Loss in Adults: A Systematic Review and Meta-Analysis

In this systematic review and meta-analysis, GLP-1 RAs produced greater weight loss among women than men; however, their efficacy was consistent across other important subpopulations.

The effects of anti-osteoporotic medication on fracture healing and outcomes: a systematic review and meta-analysis

On the basis of these analyses, bisphosphonate therapy did not appear to affect the time to or rate of fracture healing.

Circulating Lycopene and β-Carotene Levels Are Inversely Associated with Carotid Intima-Media Thickness: A Systematic Review and Meta-Analysis

The effect appears more pronounced in men, highlighting potential sex-specific differences in carotenoid metabolism and cardiovascular risk modulation.

Comparative Effects of Dietary Protein, Creatine, and Omega-3 Supplementation on Muscle Strength, Endurance, and Recovery in Trained Athletes: A Systematic Review and Network Meta-Analysis

These findings reveal an outcome-specific efficacy pattern supporting targeted supplementation strategies aligned with primary training objectives in athletic populations.

Pharmacological Interventions for Weight Reduction in Patients With Schizophrenia Treated With Antipsychotics: A Systematic Review and Network Meta-Analysis

This systematic review and network meta-analysis found substantial variability in weight-related outcomes across pharmacological interventions for antipsychotic-treated individuals with SSDs.

Complex Effects of B-Vitamin Combinations on Cardiovascular Diseases: A Systematic Review and Meta-Analysis of Randomized Controlled Trials over Three Decades

Overall, B-vitamin combinations do not confer consistent benefit for major cardiovascular outcomes but may reduce stroke and MACE in selected primary prevention populations, suggesting that baseline cardiovascular risk and regional folic acid fortification modify treatment effects and should guide future trial design and clinical use.

Calcium, vitamin D, or combined supplementation to prevent fractures and falls: systematic review and meta-analysis

Based on absolute risk reductions and thresholds considered clinically meaningful, this review found little to no benefits from use of calcium, vitamin D, or combined supplementation on the prevention of fractures and falls.

Aspirin and other nonsteroidal anti-inflammatory drugs (NSAIDs) for preventing colorectal cancer and colorectal adenoma in the general population

It is not possible to draw definitive conclusions or outline specific implications for the routine use of aspirin for CRC primary prevention based on the current evidence.

Differential Acute Kidney Injury Profiles of GLP-1RAs and SGLT2is: A Network Meta-Analysis

Further prospective trials are needed to clarify causal mechanisms and inform clinical decision-making.

Lacto-ovo-vegetarian and vegan diets in children and adolescents: a systematic review and meta-analysis of nutritional and health outcomes

These findings underscore the need for careful dietary planning and supplementation in lacto-ovo-vegetarian and vegan children.

Comparative Effectiveness of Pharmacological and Non-Pharmacological Interventions for Nausea and Vomiting in Pregnancy: A Systematic Review and Network Meta-Analysis

Conclusions: This study indicates that both pharmacological (vitamin B6, metoclopramide, dimenhydrinate) and non-pharmacological (ginger, quince, acupressure, acupuncture) interventions might be effective in reducing symptoms of nausea and vomiting in pregnancy.

Anti-inflammatory agents after hip and shoulder arthroplasty: A systematic review and meta-analysis

Because data were limited and clinically heterogeneous, the findings should not be interpreted as evidence favoring a specific drug class, dose, route, or timing.

Preventing Hand-Foot Syndrome in Patients With Cancer: A Systematic Review and Network Meta-Analysis

In this systematic review and network meta-analysis, diclofenac and silymarin were the most effective preventive strategies for HFS, with silymarin requiring confirmation in a larger randomized trial.

The Effects of Seaweed and Microalgae Supplementation on Exercise Performance and Recovery: A Systematic Review and Meta-Analysis

High-quality, multi-center RCTs incorporating mechanistic endpoints are needed to clarify optimal application and to develop athlete-specific recommendations.

Effect of Probiotic and Synbiotic Oral Supplementation in Autoimmune Diseases: An Updated Systematic Review and Meta-Analysis of Randomized Controlled Trials

Oral probiotic supplementation lowers the levels of some inflammatory markers in patients with autoimmune diseases.

Dose-Response Effect of Oral Caffeine Use on Aerobic Exercise Performance: A Systematic Review and Meta-Analysis

This is the first meta-analysis specifically focused on aerobic time-trial performance to suggest that pre-exercise ingestion of low caffeine doses (1.3-3 mg·kg-1) may enhance endurance performance by reducing time-trial completion time.

Folic acid supplementation and malaria susceptibility and severity among people taking antifolate antimalarial drugs in endemic areas

Malaria prevention: None of the included trials reported primary outcomes.

Creatine monohydrate for lean mass, strength, and bone density in postmenopausal women: a systematic review and meta-analysis

In postmenopausal women, creatine, particularly ≥ 5 g·day⁻¹ with RT, yields small but meaningful gains in lean mass and strength without evidence of harm.

Nabiximols in Multiple Sclerosis: Beyond Spasticity-An Exploratory Systematic Review and Meta-Analysis of Symptomatic Outcomes

However, the evidence certainty was low to very low, and these findings should be considered exploratory.

Pharmacological treatments for Friedreich ataxia

In this updated Cochrane systematic review, meta-analysis of results on the ataxia rating scale showed that pharmacological treatments probably make little or no difference compared with placebo after 12 months of treatment.

QTc changes and early major adverse cardiovascular events associated with antidepressant treatment for major depressive disorder in adults: individual participant data network meta-regression of double blind randomised trials

The effect of specific antidepressants on QTc interval differed between adults with depression.

Explore the Optimal Treatment Regimen Across Combinations of Variate Protein Sources and Exercise Modalities and Its Associated Factors in Older Adults: A Network Meta-Analysis and Meta-Regression of Randomized Controlled Trials

The treatment efficacy appears to be moderated by the participant's conditions, PS resource, and PS dose, particularly the outcome of muscle mass and strength.

Comparative effects of drugs for adults with overweight or obesity: systematic review and network meta-analysis

Obesity drugs produce variable weight loss at one year, with larger benefits generally accompanied by greater harms and discontinuation.

Metformin in High Metabolic Risk Pregnancies - A Patient-Level Meta-Analysis

In this IPD meta-analysis, metformin was not associated with a reduction in GDM, but was associated with an increase in gestational age at delivery.

Evaluating Reduced Use and Abstinence as Outcomes in Pharmacotherapy Trials for Stimulant Use Disorder: A Meta-Analysis of 12 Randomized Controlled Trials

The present findings of this meta-analysis underscore the importance of evaluating a continuum of outcomes rather than focusing solely on abstinence in RCTs.

Efficacy and mechanisms of Xiangsha Liujunzi Decoction for gastroesophageal reflux disease: A study integrating meta-analysis, network pharmacology and molecular docking

XSLJZD may improve RE symptoms as an adjunctive therapy, but the evidence is low in certainty.

Caffeine and IBD Risk: A Meta-Analysis

The relationship between caffeine intake and IBD risk varies by region, age, caffeine source, smoking, and education level.

Ginkgo biloba for cognitive impairment and dementia

In people with dementia, there may be small to moderate benefits at six months for global status, cognition, and ADLs.

Anabolic androgen therapy in critically ill adults: A systematic review and meta-analysis.