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Ada9.0

Adapalene

Moderate safety

Evidence

Evidence Score9/10

Studies: 8

Meta-analyses: 1

Dosage & timing

Dosage:

Topical use. Adapalene 0.1% (OTC) or 0.3% (prescription) gel/cream is applied as a thin layer to the whole affected area once daily, usually at night, starting every other day and building to nightly as tolerated. Full benefit takes ~8-12 weeks. There is no oral or systemic dose — it is not ingested. It is most effective combined with benzoyl peroxide. This library does not provide an ingestion protocol.

Best Time:

Evening

Can take on empty stomach

Form:

Adapalene 0.1% gel/cream (OTC), applied nightly to the whole area

What you'll notice

ℹ️ A topical retinoid drug — not a supplementneutral

Throughout

✨ Clears comedonal and inflammatory acnepositive

8-12 weeks

✅ Better tolerated than older retinoidspositive

Throughout

Safety

Moderate safety

Contraindications:

For topical (skin) use only — not for ingestion, not for injection
Pregnancy and breastfeeding — retinoids are generally avoided as a precaution
Known allergy/sensitivity to adapalene or formulation excipients

Drug Interactions:

Other irritating actives (other retinoids, AHAs/BHAs)
Benzoyl peroxide

Side Effects:

Dryness, redness, peeling, and stinging (retinoid dermatitis)Initial acne 'purge' / flareIncreased sun sensitivity

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