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Topical use. Adapalene 0.1% (OTC) or 0.3% (prescription) gel/cream is applied as a thin layer to the whole affected area once daily, usually at night, starting every other day and building to nightly as tolerated. Full benefit takes ~8-12 weeks. There is no oral or systemic dose — it is not ingested. It is most effective combined with benzoyl peroxide. This library does not provide an ingestion protocol.

Evening

Adapalene 0.1% gel/cream (OTC), applied nightly to the whole area

Topical cosmetic only. Centella/cica is used in serums, creams, and balms (often standardized to madecassoside/asiaticoside) applied to clean skin once or twice daily, popular for soothing and post-procedure care. There is no oral, injectable, or systemic dose in this cosmetic context — oral gotu kola is separate. This library does not provide an ingestion protocol.

Any time

Leave-on serum, cream, or balm standardized to centella triterpenes

• For topical (skin) use only — not for ingestion, not for injection
• Pregnancy and breastfeeding — retinoids are generally avoided as a precaution
• Known allergy/sensitivity to adapalene or formulation excipients

• Other irritating actives (other retinoids, AHAs/BHAs)
• Benzoyl peroxide

• For topical (skin) use only — not for ingestion in this context
• Known allergy/sensitivity to centella or its triterpenes
• Application to broken or irritated skin if it causes stinging, until healed

• Other leave-on actives