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Topical use. Adapalene 0.1% (OTC) or 0.3% (prescription) gel/cream is applied as a thin layer to the whole affected area once daily, usually at night, starting every other day and building to nightly as tolerated. Full benefit takes ~8-12 weeks. There is no oral or systemic dose — it is not ingested. It is most effective combined with benzoyl peroxide. This library does not provide an ingestion protocol.

Evening

Adapalene 0.1% gel/cream (OTC), applied nightly to the whole area

Topical cosmetic. Cysteamine 5% cream is typically applied once daily to areas of melasma as a short-contact treatment (left on for ~15 minutes, then washed off) to limit odor and irritation, with daily sunscreen. There is no oral or systemic use in this context. This library does not provide an ingestion protocol.

Any time

Cysteamine 5% cream (short-contact application)

• For topical (skin) use only — not for ingestion, not for injection
• Pregnancy and breastfeeding — retinoids are generally avoided as a precaution
• Known allergy/sensitivity to adapalene or formulation excipients

• Other irritating actives (other retinoids, AHAs/BHAs)
• Benzoyl peroxide

• For topical (skin) use only — not for ingestion, not for injection
• Known allergy/sensitivity to cysteamine
• Application to broken, irritated, or sunburned skin until healed

• Other irritating actives (acids, retinoids)