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Afa5.0

Afamelanotide

Limited safety

Evidence

Evidence Score5/10

Studies: 10

Meta-analyses: 0

Dosage & timing

Dosage:

Approved EPP regimen is a single 16 mg controlled-release SUBCUTANEOUS IMPLANT inserted by a clinician approximately every 60 days. There is NO consumer dose — afamelanotide is a prescription drug administered in a clinical setting, not a self-dosed supplement.

Best Time:

Any time

Can take on empty stomach

Form:

16 mg subcutaneous controlled-release implant (prescription, clinician-administered)

What you'll notice

☀️ More pain-free time in sunlight (EPP)positive

Over each ~60-day implant cycle

🟤 Diffuse skin pigmentation (tanning)trade-off

Days to weeks

🩹 Faster vitiligo repigmentation (with phototherapy)positive

8-24 weeks

Safety

Limited safety

Contraindications:

Use outside a prescriber's care — afamelanotide is a prescription drug, not a self-administered supplement
Pregnancy and breastfeeding (not established as safe)
Personal history of melanoma or numerous/atypical moles without specialist oversight

Drug Interactions:

Photosensitizing medications / phototherapy
Anticoagulants / antiplatelets

Side Effects:

Diffuse skin hyperpigmentationHeadacheImplant-site reaction (pain, erythema)

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