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Aic3.1

AICAR (Acadesine)

Limited safety

Evidence

Evidence Score3.1/10

Studies: 6

Meta-analyses: 1

Dosage & timing

Dosage:

No legitimate or recommended dose — AICAR is an unapproved, WADA-banned research chemical with no validated human regimen. We do NOT provide a dosing protocol. The only human dosing on record is intravenous infusion of acadesine during cardiac surgery (0.1 mg/kg/min for ~7 hours), which is a hospital ischemia protocol, not an exercise or longevity dose, and which failed its definitive trial.

Best Time:

Any time

Can take on empty stomach

Form:

None — unapproved, WADA-banned research chemical

What you'll notice

ℹ️ No human exercise / performance evidenceneutral

Throughout

🏃 Increased running endurance (mice)neutral

Weeks (in mice)

🫀 Cardiac-surgery protection — negative in the definitive trialtrade-off

Perioperative (human)

Safety

Limited safety

Contraindications:

Not an approved medicine and not a regulated dietary supplement — unapproved grey-market research chemical; do not self-source
Banned by WADA in and out of competition — disqualifying for any tested athlete
No human exercise/longevity safety data exists — every such conclusion would be an extrapolation from animals

Drug Interactions:

Metformin / other AMPK activators
Glucose-lowering drugs (insulin / sulfonylureas)
Anti-gout / urate-handling drugs

Side Effects:

Transient hyperuricemia (raised serum uric acid)Unknown human side-effect profile for exercise/longevity useHarm from an unregulated, impure or non-sterile product

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