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Ali4.5

Alirocumab (Praluent)

Limited safety

Evidence

Evidence Score4.5/10

Studies: 6

Meta-analyses: 2

Dosage & timing

Dosage:

Prescription dosing is 75 mg or 150 mg subcutaneously every 2 weeks (a 300 mg every-4-weeks option exists), titrated by a clinician to the LDL-C target. A prescription drug; not a self-administered supplement regimen.

Best Time:

Any time

Can take on empty stomach

Form:

Subcutaneous prefilled pen/syringe (alirocumab)

What you'll notice

📉 Large LDL-C reductionpositive

Within weeks

❤️ Fewer cardiovascular eventspositive

Months to years

🫀 Possible mortality benefitpositive

Years

Safety

Limited safety

Contraindications:

Known serious hypersensitivity to alirocumab or excipients
Pregnancy (limited data; lipid lowering generally deferred in pregnancy)

Drug Interactions:

Statins
Other lipid-lowering agents (ezetimibe)

Side Effects:

Injection-site reactionNasopharyngitis / flu-like symptomsHypersensitivity / allergic reaction

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