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Arl3.0

Argireline

High safety

Evidence

Evidence Score3/10

Studies: 6

Meta-analyses: 0

Dosage & timing

Dosage:

Topical cosmetic only. Argireline is typically formulated at 5-10% in leave-on serums, creams, or gels and applied to the target area (e.g., crow's-feet, forehead) twice daily. There is no oral, injectable, or systemic dose — it is not ingested. Concentration and formulation drive how much actually penetrates the skin. This library does not provide an ingestion protocol.

Best Time:

Any time

Can take on empty stomach

Form:

Leave-on topical cosmetic (serum, cream, or gel) at 5-10%

What you'll notice

ℹ️ Cosmetic, appearance-only — not a health effectneutral

Throughout

💧 Reduced appearance of fine lines (small trials)positive

4-8 weeks

✅ Generally well tolerated on skinpositive

Throughout

Safety

High safety

Contraindications:

For topical (skin) use only — not for ingestion, not for injection
Known allergy or sensitivity to the peptide or formulation excipients
Application to broken, irritated, or compromised skin until healed

Drug Interactions:

Other topical actives (retinoids, acids)
Injectable botulinum toxin (BoNT)

Side Effects:

Local skin irritation or rednessContact allergic reaction

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