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Bak4.0

Bakuchiol

High safety

Evidence

Evidence Score4/10

Studies: 6

Meta-analyses: 0

Dosage & timing

Dosage:

Topical cosmetic only. Bakuchiol is typically formulated around 0.5-1% in leave-on serums or creams and applied to clean skin once or twice daily. Unlike retinol it is not photolabile, so it can be used AM or PM, though daily sunscreen is still recommended. There is no oral, injectable, or systemic dose — it is not ingested. This library does not provide an ingestion protocol.

Best Time:

Any time

Can take on empty stomach

Form:

Leave-on topical serum or cream (0.5-1% purified bakuchiol)

What you'll notice

ℹ️ Cosmetic, appearance-only — not a health effectneutral

Throughout

💆 Reduced wrinkle appearance (comparable to retinol)positive

8-12 weeks

✅ Better tolerated than retinolpositive

Throughout

Safety

High safety

Contraindications:

For topical (skin) use only — not for ingestion, not for injection
Known allergy or sensitivity to bakuchiol or formulation excipients
Application to broken, irritated, or compromised skin until healed

Drug Interactions:

Other leave-on actives (retinoids, acids)

Side Effects:

Mild local irritation or rednessContact allergic reaction

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