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A-F grade per outcome, combining overall evidence with goal-specific relevance. A = strong evidence; F = insufficient. Hover a badge for details.
Topical cosmetic only. Bakuchiol is typically formulated around 0.5-1% in leave-on serums or creams and applied to clean skin once or twice daily. Unlike retinol it is not photolabile, so it can be used AM or PM, though daily sunscreen is still recommended. There is no oral, injectable, or systemic dose — it is not ingested. This library does not provide an ingestion protocol.
Any time
Leave-on topical serum or cream (0.5-1% purified bakuchiol)
Topical cosmetic only. Matrixyl (palmitoyl pentapeptide-4 / pal-KTTKS, or the Matrixyl 3000 blend of palmitoyl tripeptide-1 + palmitoyl tetrapeptide-7) is used at very low concentrations in leave-on serums and creams — clinical benefit was shown at as little as 3 ppm pal-KTTKS, and consumer products commonly list 3-10% of the branded blend. Applied to the target area once or twice daily. There is no oral, injectable, or systemic dose — it is not ingested.
Any time
Leave-on topical cosmetic (serum or cream) containing palmitoyl pentapeptide-4 or the Matrixyl 3000 blend
Throughout
8-12 weeks
Throughout
Throughout
8-12 weeks
Cell studies
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