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Bem4.3

Bempedoic Acid

Moderate safety

Evidence

Evidence Score4.3/10

Studies: 7

Meta-analyses: 1

Dosage & timing

Dosage:

180 mg orally once daily, with or without food, under a clinician. Available alone (Nexletol) or co-formulated with ezetimibe 10 mg (Nexlizet). A prescription drug — dosing is set by a prescriber.

Best Time:

Any time

Can take on empty stomach

Form:

Oral tablet (bempedoic acid 180 mg)

What you'll notice

📉 LDL-cholesterol reductionpositive

Weeks (full effect by ~12 weeks)

🫀 Cardiovascular-event reductionpositive

Months to years

💪 Avoids statin-type muscle painpositive

Throughout use

Safety

Moderate safety

Contraindications:

Concurrent simvastatin >20 mg or pravastatin >40 mg (bempedoic acid raises their levels)
Active gout flare without management
History of tendon rupture related to similar agents

Drug Interactions:

Simvastatin / pravastatin
Corticosteroids / fluoroquinolones

Side Effects:

Hyperuricemia / goutRaised liver enzymes / creatinineTendon rupture

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