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Bpo9.0

Benzoyl Peroxide

Moderate safety

Evidence

Evidence Score9/10

Studies: 6

Meta-analyses: 1

Dosage & timing

Dosage:

Topical OTC use. Benzoyl peroxide is used at 2.5-10% in gels, creams, and washes, applied to acne-prone areas once or twice daily; lower strengths (2.5-5%) are usually as effective as 10% with less irritation. There is no oral or systemic dose — it is not ingested. It is often combined with a retinoid (e.g. adapalene) for greater effect. This library does not provide an ingestion protocol.

Best Time:

Any time

Can take on empty stomach

Form:

Leave-on gel/cream (2.5-5%) or a fixed combination with a retinoid

What you'll notice

ℹ️ A frontline OTC acne medicine — not a supplementneutral

Throughout

✨ Reduces inflammatory and comedonal acnepositive

4-12 weeks

🛡️ Does not promote antibiotic resistancepositive

Throughout

Safety

Moderate safety

Contraindications:

For topical (skin) use only — not for ingestion, not for injection
Known allergy/sensitivity to benzoyl peroxide (true allergic contact dermatitis is uncommon but possible)
Application to broken, severely inflamed, or sunburned skin until healed

Drug Interactions:

Topical retinoids degraded by oxidation (some tretinoin formulations)
Other irritating actives (acids, other retinoids)

Side Effects:

Dryness, peeling, redness, and burningBleaching of fabrics, towels, and hairAllergic contact dermatitis

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