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Bon3.5

Bonito Peptides

High safety

Evidence

Evidence Score3.5/10

Studies: 12

Meta-analyses: 0

Dosage & timing

Dosage:

Trials used ~1.5-3 mg Val-Tyr/day (e.g. a 3 mg VY drink, twice daily), or labeled katsuobushi-oligopeptide products providing the equivalent; follow product labeling

Best Time:

Any time · with food

Take with food

Form:

Katsuobushi oligopeptide (Val-Tyr-standardized) drink or capsule

What you'll notice

📉 Modest blood-pressure reductionpositive

1-4 weeks

➖ Little/no effect in normotensivesneutral

Throughout use

✅ Generally well toleratedpositive

Throughout use

Safety

High safety

Contraindications:

Fish allergy (bonito/sardine-derived)
Caution if already on ACE-inhibitor / antihypertensive medication (theoretical additive blood-pressure lowering)

Drug Interactions:

ACE inhibitors / ARBs / antihypertensives
Potassium-sparing agents / potassium supplements

Side Effects:

None notable in trialsAllergic reaction (fish-allergic individuals)

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