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Cpt3.5

Captopril

Limited safety

Evidence

Evidence Score3.5/10

Studies: 5

Meta-analyses: 0

Dosage & timing

Dosage:

Off-label longevity use mirrors low antihypertensive dosing (captopril is short-acting; longer-acting ACE inhibitors like lisinopril/ramipril are often used) under a clinician. Not an approved longevity regimen; blood pressure and potassium should be monitored.

Best Time:

Any time

Can take on empty stomach

Form:

Oral tablet (or a longer-acting ACE inhibitor)

What you'll notice

⏳ Lifespan extension (model organisms)positive

Unknown in humans

❤️ Cardiovascular mortality benefitpositive

Months to years

🫘 Kidney protectionpositive

Years

Safety

Limited safety

Contraindications:

Pregnancy (fetal harm)
History of ACE-inhibitor angioedema
Bilateral renal artery stenosis

Drug Interactions:

Potassium-sparing diuretics / potassium / salt substitutes
NSAIDs
Lithium

Side Effects:

Dry coughHyperkalemiaAngioedema

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