Compare Supplements

Side-by-side comparison of 2 supplements

Cah4.0

Casein Hydrolysate

High safety

Ltp4.5

Lactotripeptides

High safety

Evidence

Evidence Score4/10

Studies: 11

Meta-analyses: 0

Evidence Score4.5/10

Studies: 12

Meta-analyses: 7

Dosage & timing

Dosage:

150 mg/day of standardized αs1-casein hydrolysate (Lactium), taken once daily; acute studies have used ~200 mg

Best Time:

Evening

Can take on empty stomach

Form:

αs1-Casein hydrolysate standardized to α-casozepine (Lactium)

Dosage:

~3-5 mg combined VPP + IPP per day (the dose used in most positive fermented-milk trials)

Best Time:

Any time · with food

Take with food

Form:

Fermented milk (Lactobacillus helveticus)

What you'll notice

😌 Reduced stress-related symptomspositive

2-4 weeks

🧘 Blunted acute stress responsepositive

Within hours of a dose

🌙 Sleep-diary improvements (inconsistent)neutral

2-4 weeks

📉 Small systolic BP reductionpositive

4-8 weeks

📊 Smaller diastolic BP reductionpositive

4-8 weeks

🌏 Effect depends on populationneutral

Throughout use

Safety

High safety

Contraindications:

Milk / dairy protein allergy (it is a bovine milk-protein fraction)

Drug Interactions:

Benzodiazepines / sedatives / hypnotics
CNS depressants / alcohol

Side Effects:

Mild drowsinessMild GI discomfort

High safety

Contraindications:

Milk / dairy allergy (these are milk-casein-derived peptides)
Galactosemia (avoid milk-based products)

Drug Interactions:

ACE inhibitors / antihypertensive drugs

Side Effects:

Generally well tolerated; side effects comparable to placebo in trialsDairy-related GI upset (in lactose-intolerant individuals consuming milk-based products)

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