Compare Supplements

Side-by-side comparison of 1 supplements

Clc3.0

Colchicine

Limited safety

Evidence

Evidence Score3/10

Studies: 6

Meta-analyses: 1

Dosage & timing

Dosage:

Off-label cardiovascular/geroprotective use is low-dose: 0.5 mg once daily (the LoDoCo2 regimen) under a clinician. Acute gout uses higher short-course dosing. Not an approved longevity regimen; mind the drug interactions.

Best Time:

Any time · with food

Take with food

Form:

Low-dose oral tablet (0.5 mg/day)

What you'll notice

❤️ Reduced cardiovascular eventspositive

Months to years

🔥 Lowered inflammationpositive

Weeks

ℹ️ Debated net mortalityneutral

Trial endpoints

Safety

Limited safety

Contraindications:

Significant renal or hepatic impairment (with interacting drugs)
Concurrent strong CYP3A4/P-gp inhibitors
Pregnancy (relative; specialist-directed in FMF)

Drug Interactions:

Strong CYP3A4 / P-gp inhibitors (clarithromycin, some statins, grapefruit)
Statins / fibrates

Side Effects:

Diarrhea / GI upsetMyopathy / neuromyopathyBone-marrow suppression / severe toxicity (overdose)

Want to compare more supplements?

Loading comparison...