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Cys6.0

Cysteamine (topical)

Moderate safety

Evidence

Evidence Score6/10

Studies: 7

Meta-analyses: 1

Dosage & timing

Dosage:

Topical cosmetic. Cysteamine 5% cream is typically applied once daily to areas of melasma as a short-contact treatment (left on for ~15 minutes, then washed off) to limit odor and irritation, with daily sunscreen. There is no oral or systemic use in this context. This library does not provide an ingestion protocol.

Best Time:

Any time

Can take on empty stomach

Form:

Cysteamine 5% cream (short-contact application)

What you'll notice

ℹ️ A hydroquinone-free depigmenterneutral

Throughout

🌗 Reduced melasma / more even tonepositive

8-16 weeks

⚠️ Not superior to hydroquinoneneutral

Throughout

Safety

Moderate safety

Contraindications:

For topical (skin) use only — not for ingestion, not for injection
Known allergy/sensitivity to cysteamine
Application to broken, irritated, or sunburned skin until healed

Drug Interactions:

Other irritating actives (acids, retinoids)

Side Effects:

Erythema and burningUnpleasant sulfur/thiol odor

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