Compare Supplements

Side-by-side comparison of 2 supplements

Dul7.0

Dulaglutide

Limited safety

B127.5

Vitamin B12

High safety

Evidence

Evidence Score7/10

Studies: 12

Meta-analyses: 2

Evidence Score7.5/10

Studies: 79

Meta-analyses: 20

Dosage & timing

Dosage:

Prescription-only, clinician-prescribed. Subcutaneous 0.75 mg once weekly to start, usually escalated to 1.5 mg; 3.0 mg and 4.5 mg once-weekly doses are available for additional glycemic lowering. DO NOT self-dose.

Best Time:

Any time

Can take on empty stomach

Form:

Subcutaneous once-weekly pen (Trulicity)

Dosage:

500-1000mcg daily for maintenance; higher for deficiency

Best Time:

Morning · with food (preferred)

Can take on empty stomach

Form:

Methylcobalamin (sublingual)

What you'll notice

🩸 Improved glycemic controlpositive

Weeks to months

❤️ Reduced cardiovascular eventspositive

Months to years

⚖️ Modest weight losspositive

Months

⚡ Energy Restorationpositive

2-4 weeks

🧠 Cognitive Supportpositive

4-8 weeks

⚡ Nerve Healthpositive

Weeks to months

Safety

Limited safety

Contraindications:

Personal or family history of medullary thyroid carcinoma (MTC)
Multiple Endocrine Neoplasia syndrome type 2 (MEN2)
Prior serious hypersensitivity to dulaglutide or any GLP-1 receptor agonist

Drug Interactions:

Insulin and sulfonylureas
Oral medications (general)
Other GLP-1 receptor agonists

Side Effects:

NauseaVomiting / diarrheaGallbladder disease (cholelithiasis / cholecystitis)

High safety

Contraindications:

Leber's hereditary optic neuropathy (may worsen)
Cobalt or cobalamin hypersensitivity

Drug Interactions:

Metformin
PPIs (proton pump inhibitors)

Side Effects:

Mild GI upsetAcne-like skin eruption (high doses)Allergic reaction (rare, usually with injection)

Works well with

No synergies listed

Methylfolate

complementary

L-Methionine

enhances

Pantothenic Acid

complementary

How they work together

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