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Enc4.2

Enclomiphene

Limited safety

Evidence

Evidence Score4.2/10

Studies: 7

Meta-analyses: 0

Dosage & timing

Dosage:

Investigational / off-label — no FDA-approved dose exists. Trials studied oral enclomiphene citrate at 6.25-25 mg once daily (12.5 mg and 25 mg were the Phase-3 doses). Compounded enclomiphene is used off-label under a clinician at similar doses, but quality and content are not regulated.

Best Time:

Any time

Can take on empty stomach

Form:

Oral enclomiphene citrate (compounded; investigational — never marketed as an approved drug)

What you'll notice

🧬 Raises endogenous testosteronepositive

Weeks to a few months

👶 Preserves sperm productionpositive

Within 3-6 months

⚠️ Investigational / not FDA-approvedtrade-off

N/A

Safety

Limited safety

Contraindications:

Primary (testicular) hypogonadism — needs an intact pituitary/testis axis to work
Hormone-sensitive tumors or conditions worsened by raising testosterone/estrogen
History of venous thromboembolism (class concern for SERMs)

Drug Interactions:

Exogenous testosterone / anabolic steroids
Aromatase inhibitors / other SERMs (e.g. tamoxifen)
Estrogens

Side Effects:

Visual disturbances (blurring, flashes, floaters)Mood changes / irritabilityHeadache, hot flashes, nausea

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