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Investigational / off-label — no FDA-approved dose exists. Trials studied oral enclomiphene citrate at 6.25-25 mg once daily (12.5 mg and 25 mg were the Phase-3 doses). Compounded enclomiphene is used off-label under a clinician at similar doses, but quality and content are not regulated.

Any time

Oral enclomiphene citrate (compounded; investigational — never marketed as an approved drug)

Prescription-only and clinician-directed — this is a controlled substance, NOT a self-administered supplement, and we do not provide a non-medical dosing protocol. For context only: TRT for diagnosed hypogonadism is titrated to a mid-normal testosterone level. Intramuscular testosterone esters (cypionate/enanthate) are commonly dosed around 50–100 mg weekly (or ~100–200 mg every 2 weeks); long-acting testosterone undecanoate is dosed less frequently. Transdermal gels (~50–100 mg/day applied) and subcutaneous injection are alternative routes. Supraphysiologic anabolic-steroid doses are far higher, illegal, and dangerous — not a regimen this library endorses.

Any time

Clinician-prescribed testosterone (intramuscular ester or transdermal gel) for diagnosed hypogonadism — controlled substance, prescription-only

• Primary (testicular) hypogonadism — needs an intact pituitary/testis axis to work
• Hormone-sensitive tumors or conditions worsened by raising testosterone/estrogen
• History of venous thromboembolism (class concern for SERMs)

• Exogenous testosterone / anabolic steroids
• Aromatase inhibitors / other SERMs (e.g. tamoxifen)
• Estrogens

• Use without a prescription / without medical supervision — testosterone is a Schedule III controlled substance and prescription-only
• Active prostate cancer or active breast cancer in men
• Untreated severe erythrocytosis / hematocrit above the safe threshold

• Anticoagulants / warfarin
• Other anabolic steroids / SARMs / hCG / aromatase inhibitors
• Insulin / glucose-lowering drugs