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Side-by-side comparison of 1 supplements

Eve4.2

Everolimus

Limited safety

Evidence

Evidence Score4.2/10

Studies: 7

Meta-analyses: 1

Dosage & timing

Dosage:

No validated longevity dose. Geroscience trials used low intermittent dosing (e.g. ~0.5 mg/day or ~5 mg/week of RAD001) — unproven and not an approved regimen. Approved oncology dosing is 10 mg/day (Afinitor) and transplant dosing is trough-titrated (Zortress); both are far higher than any longevity protocol.

Best Time:

Any time

Can take on empty stomach

Form:

Oral everolimus tablet

What you'll notice

🛡️ Improved immune / vaccine responsepositive

Weeks to months

🎯 Anti-tumor (approved oncology use)positive

Months

⚠️ Immunosuppression / infection risknegative

Throughout use

Safety

Limited safety

Contraindications:

Active infection
Pregnancy / breastfeeding
Significant immunosuppression or upcoming surgery (wound healing)

Drug Interactions:

CYP3A4 inhibitors / inducers
Live vaccines
Other immunosuppressants

Side Effects:

Stomatitis (mouth ulcers)Hyperglycemia / hyperlipidemiaNon-infectious pneumonitis

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