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Exe6.0

Exenatide

Limited safety

Evidence

Evidence Score6/10

Studies: 12

Meta-analyses: 3

Dosage & timing

Dosage:

Prescription-only, clinician-directed. Subcutaneous. Byetta (twice-daily): 5 µg before two main meals, escalated to 10 µg after ~1 month. Bydureon (once-weekly extended-release): 2 mg subcutaneously once weekly. DO NOT self-dose.

Best Time:

Any time

Can take on empty stomach

Form:

Once-weekly extended-release injection (Bydureon)

What you'll notice

🩸 Improved glycemic controlpositive

Weeks to months

⚖️ Modest weight losspositive

Months

❤️ Cardiovascular: neutral primary outcomeneutral

Years

Safety

Limited safety

Contraindications:

Personal or family history of medullary thyroid carcinoma (MTC)
Multiple Endocrine Neoplasia syndrome type 2 (MEN2)
Severe renal impairment (eGFR <30 mL/min) or end-stage renal disease — exenatide is renally cleared

Drug Interactions:

Sulfonylureas and insulin
Oral medications (general)
Warfarin

Side Effects:

NauseaVomiting / diarrheaInjection-site nodules / induration (once-weekly form)

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