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Ghk3.0

GHK-Cu

Limited safety

Evidence

Evidence Score3/10

Studies: 11

Meta-analyses: 0

Dosage & timing

Dosage:

Topical cosmetic use only: leave-on serums/creams typically 1-2% GHK-Cu (≈0.05-0.2% in some formulas), applied once or twice daily. No validated systemic dose exists.

Best Time:

Any time

Can take on empty stomach

Form:

Topical serum/cream (copper tripeptide-1)

What you'll notice

✨ Skin appearance (topical, weakly evidenced)positive

Weeks to months (topical)

🩹 Wound/matrix repair (preclinical)neutral

N/A (preclinical)

⚠️ Injectable use unprovenneutral

N/A

Safety

Limited safety

Contraindications:

Injectable/systemic use (no human safety data; copper-toxicity risk)
Wilson's disease or other copper-overload disorders (avoid copper-delivering products)
Pregnancy/breastfeeding (not studied)

Drug Interactions:

Topical retinoids / acids (concurrent skincare)
Copper-chelating or copper-modifying therapy

Side Effects:

Local skin irritation / redness (topical)Contact sensitivity / allergic reaction (topical)Unknown systemic effects (injectable)

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