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Glc6.0

Glycolic Acid

Moderate safety

Evidence

Evidence Score6/10

Studies: 6

Meta-analyses: 1

Dosage & timing

Dosage:

Topical cosmetic only. Leave-on glycolic acid is used at roughly 5-15% in lotions/serums (often at low pH), applied to clean skin a few nights per week and building as tolerated; professional peels (20-70%) are applied in-office at intervals. There is no oral, injectable, or systemic dose — it is not ingested. Pair with daily sunscreen. This library does not provide an ingestion protocol.

Best Time:

Evening

Can take on empty stomach

Form:

Leave-on lotion or serum (≈5-15% glycolic acid)

What you'll notice

ℹ️ Cosmetic, appearance-only — not a health effectneutral

Throughout

✨ Smoother texture and more even tonepositive

8-12 weeks

💆 Modest fine-line improvement (weaker than retinoids)neutral

8-16 weeks

Safety

Moderate safety

Contraindications:

For topical (skin) use only — not for ingestion, not for injection
Known allergy or sensitivity to AHAs
Active eczema, dermatitis, or broken/sunburned skin until healed

Drug Interactions:

Other leave-on actives (retinoids, other acids, benzoyl peroxide)

Side Effects:

Stinging, redness, or peelingIncreased sun sensitivityPost-inflammatory hyperpigmentation (esp. darker skin, from over-peeling)

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