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Gnr4.0

Gonadorelin

Limited safety

Evidence

Evidence Score4/10

Studies: 11

Meta-analyses: 0

Dosage & timing

Dosage:

Prescription-only and delivery-dependent. Diagnostically, a single bolus (e.g. 100 µg) is given. For fertility, pulsatile delivery via an infusion pump is required — historic regimens used ~75 ng/kg/pulse (women, often IV) or 5-25 ng/kg/pulse titrated (men, sc), every ~90 minutes. No validated dietary-supplement dose exists; intermittent subcutaneous bolus dosing as used in some TRT clinics is off-label and not validated.

Best Time:

Any time

Can take on empty stomach

Form:

Gonadorelin acetate (prescription; pulsatile infusion pump for fertility, single bolus for diagnostics)

What you'll notice

🧪 Acute LH/FSH response (diagnostic, well-documented)positive

Within 30-60 minutes

👶 Ovulation & pregnancy (pulsatile, in the right patients)positive

Weeks (within a few cycles)

🔬 Spermatogenesis in hypogonadotropic men (pulsatile)positive

Months

Safety

Limited safety

Contraindications:

Pregnancy (fertility treatment is supervised; not a self-administered agent)
Hormone-sensitive tumors / conditions worsened by gonadal stimulation
Use without medical supervision

Drug Interactions:

Exogenous testosterone / anabolic steroids
GnRH agonists / antagonists (e.g. leuprolide, cetrorelix)
Glucocorticoids / dopamine agonists / spironolactone

Side Effects:

Injection-site reaction (pain, redness, swelling)Multiple pregnancy / ovarian enlargement (fertility use)Headache, flushing, nausea, abdominal discomfort

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