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HCG5.5

HCG (Human Chorionic Gonadotropin)

Limited safety

Evidence

Evidence Score5.5/10

Studies: 7

Meta-analyses: 1

Dosage & timing

Dosage:

Prescription-only and indication-dependent. For fertility preservation / intratesticular-testosterone maintenance on TRT, small studies used ~125-500 IU subcutaneously every other day. For spermatogenesis induction in hypogonadotropic hypogonadism, typically ~1,000-2,500 IU two to three times weekly (often combined with FSH), titrated to response. For female ovulation/oocyte-maturation trigger, a single dose (~5,000-10,000 IU urinary or 250 µg recombinant). No dietary-supplement dose exists.

Best Time:

Any time

Can take on empty stomach

Form:

Prescription hCG — recombinant (choriogonadotropin alfa) or urinary-derived, by injection

What you'll notice

🧪 Maintains intratesticular testosterone on TRT (randomized dose-response)positive

Weeks

👶 Preserves spermatogenesis during testosterone therapypositive

Months

🔬 Induces spermatogenesis in hypogonadotropic menpositive

Months

Safety

Limited safety

Contraindications:

Hormone-sensitive tumors (e.g. prostate, breast) or other androgen/estrogen-dependent conditions
Known hypersensitivity to hCG
Use without medical supervision

Drug Interactions:

Exogenous testosterone / anabolic steroids
FSH / hMG (menotropins)
Aromatase inhibitors (e.g. anastrozole)

Side Effects:

Injection-site reaction (pain, redness, swelling)Estradiol elevation / gynecomastia / water retention (men)Ovarian hyperstimulation syndrome (women)

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