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Hq7.0

Hydroquinone

Limited safety

Evidence

Evidence Score7/10

Studies: 8

Meta-analyses: 1

Dosage & timing

Dosage:

Prescription topical. Hydroquinone is used at 2-4% (often as the triple-combination with a retinoid and a mild corticosteroid), applied to pigmented areas usually at night, in time-limited courses (commonly with treatment breaks) under clinician supervision, always with daily sunscreen. There is no oral or systemic use. Avoid indefinite continuous use because of ochronosis risk. This library does not provide an ingestion protocol.

Best Time:

Evening

Can take on empty stomach

Form:

Hydroquinone 2-4% cream or the triple-combination (with retinoid + mild steroid), under a clinician

What you'll notice

ℹ️ The gold-standard depigmenter — now a regulated drugneutral

Throughout

🌗 Strong reduction of melasma and dark spotspositive

8-12 weeks

🔴 Irritation and rebound pigmentationnegative

Throughout

Safety

Limited safety

Contraindications:

For topical (skin) use only — not for ingestion, not for injection
Prolonged continuous or high-strength use (ochronosis risk) — use time-limited courses
Known allergy/sensitivity to hydroquinone

Drug Interactions:

Peroxides (benzoyl peroxide, hydrogen peroxide)
Other irritating actives (retinoids, acids)

Side Effects:

Irritant/contact dermatitis (redness, burning, peeling)Exogenous ochronosis (paradoxical darkening)Rebound hyperpigmentation after stopping

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