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Inc4.1

Inclisiran (Leqvio)

Moderate safety

Evidence

Evidence Score4.1/10

Studies: 7

Meta-analyses: 2

Dosage & timing

Dosage:

284 mg (300 mg inclisiran sodium) by subcutaneous injection administered by a healthcare professional on day 1, again at day 90 (month 3), then every 6 months thereafter. A prescription drug; this is the approved regimen, not a self-directed supplement protocol.

Best Time:

Any time

Can take on empty stomach

Form:

Prefilled subcutaneous injection (inclisiran 284 mg)

What you'll notice

📉 Sustained ~50% LDL-cholesterol reductionpositive

Weeks to months; sustained

🗓️ Twice-yearly dosing (adherence advantage)positive

Ongoing

⏳ Cardiovascular outcomes NOT yet proventrade-off

Outcomes trials ongoing

Safety

Moderate safety

Contraindications:

Known hypersensitivity to inclisiran or excipients
Not a substitute for a clinician's evaluation — prescription drug only

Drug Interactions:

Statins / ezetimibe
PCSK9 monoclonal antibodies (evolocumab / alirocumab)

Side Effects:

Injection-site reaction (pain, redness, induration)Arthralgia / limb painHypersensitivity reaction

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