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Ipa2.5

Ipamorelin

Limited safety

Evidence

Evidence ScoreNot scored

Studies: 12

Meta-analyses: 0

Dosage & timing

Dosage:

No validated human dose for any physique or anti-aging use. The published human studies were intravenous and hospital-based: an early dose-escalation PK/PD study (4.21-140.45 nmol/kg IV) confirmed a GH pulse, and the phase-2 ileus trial used 0.03 mg/kg IV twice daily. Grey-market subcutaneous use is unstandardized and not endorsed.

Best Time:

Any time

Can take on empty stomach

Form:

None (research compound, not for human use)

What you'll notice

🧬 GH pulse release (animal + human PK)positive

Acute (minutes after dosing)

ℹ️ No proven human benefitneutral

Throughout use

➖ Failed phase-2 ileus endpointneutral

N/A

Safety

Limited safety

Contraindications:

Pregnancy and breastfeeding (contraindicated — never studied, GH-axis effects)
Active or prior malignancy (GH/IGF-1 elevation is theoretically growth-promoting)
Competitive athletes subject to anti-doping rules (WADA-prohibited)

Drug Interactions:

Insulin / antidiabetic drugs
Corticosteroids
Other growth-hormone secretagogues / GH

Side Effects:

Water retention / peripheral edemaReduced insulin sensitivity / higher blood glucoseInjection-site reactions / infection risk

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