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Let5.0

Letrozole

Limited safety

Evidence

Evidence Score5/10

Studies: 8

Meta-analyses: 2

Dosage & timing

Dosage:

Indication-specific and clinician-directed. Ovulation induction: 2.5-7.5 mg once daily for 5 days early in the cycle (typically days 3-7). Breast cancer: 2.5 mg once daily continuously. Off-label male use mirrors 2.5 mg once to a few times weekly (NOT daily) titrated to testosterone/estradiol — a prescription drug, not an approved supplement regimen.

Best Time:

Any time

Can take on empty stomach

Form:

Oral letrozole 2.5 mg tablet (Femara / generic)

What you'll notice

👶 Ovulation induction (beats clomiphene)positive

Per cycle (days 3-7 dosing)

🧬 Raises testosterone / lowers estradiol (men)neutral

Weeks to months

🦴 Bone & lipid cost of low estrogentrade-off

Months to years

Safety

Limited safety

Contraindications:

Pregnancy (teratogenic risk) — used to induce ovulation, but stopped once pregnancy occurs
Premenopausal women for breast-cancer indication without ovarian suppression
Hypersensitivity to letrozole

Drug Interactions:

Tamoxifen / other estrogen-modulating agents
Exogenous estrogen / hormone therapy
Exogenous testosterone / anabolic steroids

Side Effects:

Hot flashesFatigue / dizzinessArthralgia / musculoskeletal aches

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