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Li3.0

Lithium (low-dose)

Limited safety

Evidence

Evidence Score3/10

Studies: 6

Meta-analyses: 0

Dosage & timing

Dosage:

Geroprotective interest centers on LOW doses far below bipolar dosing. The OTC microdose form is lithium orotate (~1–5 mg elemental lithium; see that supplement). Therapeutic lithium carbonate (hundreds of mg, blood-level-monitored) is a different, higher-risk regimen used for bipolar disorder under a clinician. No validated longevity dose exists.

Best Time:

Any time · with food

Take with food

Form:

Low-dose / lithium orotate (microdose)

What you'll notice

📊 Lower mortality (epidemiology)positive

Population-level

🧠 Lower dementia risk (associational)positive

Years

⏳ Lifespan (model-organism, mixed)neutral

Unknown in humans

Safety

Limited safety

Contraindications:

Significant renal impairment
Dehydration / significant sodium depletion
Pregnancy (cardiac malformation risk at therapeutic doses)

Drug Interactions:

NSAIDs / ACE inhibitors / thiazide diuretics
Dehydration / low-sodium states

Side Effects:

Tremor / GI upsetThyroid suppression (hypothyroidism)Kidney effects / lithium toxicity

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