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Lix5.0

Lixisenatide

Limited safety

Evidence

Evidence Score5/10

Studies: 11

Meta-analyses: 6

Dosage & timing

Dosage:

Prescription-only, clinician-directed. Subcutaneous 20 µg once daily within the hour before the first meal of the day, after a 10 µg starting dose for 14 days. DO NOT self-dose.

Best Time:

Morning

Can take on empty stomach

Form:

Subcutaneous once-daily injection (Adlyxin / Lyxumia)

What you'll notice

🩸 Modest glycemic controlpositive

Weeks (24-week endpoints)

🍽️ Strong postprandial glucose loweringpositive

Per meal / weeks

⚖️ Small / neutral weight effectneutral

Months

Safety

Limited safety

Contraindications:

Personal or family history of medullary thyroid carcinoma (MTC) — GLP-1 class C-cell tumor warning
Multiple Endocrine Neoplasia syndrome type 2 (MEN2)
Prior serious hypersensitivity to lixisenatide or any GLP-1 receptor agonist

Drug Interactions:

Insulin and sulfonylureas
Oral medications (general)
Other GLP-1 receptor agonists

Side Effects:

NauseaVomiting / diarrheaSymptomatic hypoglycemia (mainly with insulin/sulfonylurea)

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