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LDN3.8

Low-Dose Naltrexone (LDN)

Limited safety

Evidence

Evidence Score3.8/10

Studies: 7

Meta-analyses: 2

Dosage & timing

Dosage:

Off-label, prescription-only. Typical LDN dosing is ~1.5–4.5 mg once daily, usually at night, often started low (~1.5 mg) and titrated to 4.5 mg. Requires a compounding pharmacy (commercial tablets are 50 mg). Not an approved or standardized regimen.

Best Time:

Evening

Can take on empty stomach

Form:

Compounded low-dose (1.5–4.5 mg) capsule or liquid

What you'll notice

🎯 Reduced fibromyalgia painpositive

Weeks

🛡️ Anti-inflammatory / autoimmune modulationpositive

Weeks to months

⚖️ Mixed / inconsistent resultstrade-off

Varies

Safety

Limited safety

Contraindications:

Current opioid use or opioid pain medication (precipitates withdrawal / blocks analgesia)
Acute opioid withdrawal
Significant hepatic impairment (naltrexone is hepatically metabolised)

Drug Interactions:

Opioid analgesics (and opioid-containing medicines)
Hepatotoxic drugs

Side Effects:

Sleep disturbance / vivid dreamsHeadache / nauseaLoss of opioid analgesia / withdrawal

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