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Mfn4.0

Metformin

Limited safety

Evidence

Evidence Score4/10

Studies: 7

Meta-analyses: 1

Dosage & timing

Dosage:

Off-label longevity use mirrors diabetes dosing (commonly 500–1500 mg/day of extended-release with meals) under a clinician. Not an approved longevity regimen, and unnecessary in well-controlled non-diabetics without a clear rationale.

Best Time:

With meals · with food

Take with food

Form:

Extended-release tablet

What you'll notice

📉 Glycemic controlpositive

Weeks

📊 Possible mortality benefit (epidemiology)positive

Years

🏃 May blunt exercise adaptationtrade-off

Weeks of training

Safety

Limited safety

Contraindications:

Severe renal impairment (eGFR < 30)
Acute metabolic acidosis
Conditions predisposing to lactic acidosis (severe hypoxia, decompensated heart failure)

Drug Interactions:

Iodinated contrast
Alcohol (excessive)

Side Effects:

GI upset (diarrhea, nausea)Vitamin B12 depletionLactic acidosis

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