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There is no legitimate dose. Methandrostenolone's FDA approval was withdrawn, it has no current approved medical indication, and it is a DEA Schedule III controlled substance; this library does NOT provide a body-composition dosing protocol. For historical context only: the controlled trials that established its anabolic effect used 100 mg/day for six weeks (Hervey), and mid-century clinical use was far lower (~5 mg/day). That is not an endorsement of self-administration.

Any time

None — approval withdrawn; no legitimate over-the-counter, supplement or prescription form

• Anyone seeking it for body composition or athletic performance — a DEA Schedule III controlled substance whose approval was withdrawn; possession/use is illegal, and it is not a dietary supplement
• Pre-existing liver disease or elevated liver enzymes — 17α-alkylated and hepatotoxic (cholestasis, peliosis hepatis, liver tumours)
• Known or suspected prostate or male breast carcinoma; pre-existing gynecomastia (it is strongly estrogenic)

• Warfarin / oral anticoagulants
• Hepatotoxic drugs / alcohol
• Insulin / oral hypoglycemics