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Side-by-side comparison of 1 supplements

Pmb3.8

Methenolone (Primobolan)

Limited safety

Evidence

Evidence Score3.8/10

Studies: 5

Meta-analyses: 0

Dosage & timing

Dosage:

There is no legitimate non-medical dose. Methenolone is a prescription-only, DEA Schedule III controlled substance; this library does NOT provide a body-composition dosing protocol. For historical/clinical context only: the injectable enanthate (Primobolan Depot) was given intramuscularly, and high doses (e.g. 400–1200 mg/week) were used in the older breast-cancer literature; the oral acetate is 17α-methylated and hepatically taxing. Any legitimate use is clinician-directed with lipid, liver, and hormonal monitoring. That is not an endorsement of self-administration.

Best Time:

Any time

Can take on empty stomach

Form:

Injectable enanthate (Primobolan Depot) — clinician-directed; the injectable is NOT 17α-alkylated and largely spares the liver, unlike the oral acetate

What you'll notice

🩸 Raises hemoglobin in marrow-failure anemia (old evidence)positive

Weeks to months

💪 Mild lean-mass / anti-catabolic effectneutral

Weeks

🩸 Adverse cholesterol shiftnegative

Weeks of use

Safety

Limited safety

Contraindications:

Anyone seeking it for body composition or athletic performance without a prescription — a DEA Schedule III controlled substance; possession/use without an Rx is illegal, and it is not a dietary supplement
Pre-existing liver disease or elevated liver enzymes — the oral 17α-methylated acetate is hepatotoxic
Known or suspected prostate or male breast carcinoma; hypercalcemia

Drug Interactions:

Warfarin / oral anticoagulants
Hepatotoxic drugs / alcohol (oral acetate)
Insulin / oral hypoglycemics

Side Effects:

Adverse lipid shift (low HDL, higher LDL)HPTA suppressionVirilization (women)

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