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Side-by-side comparison of 1 supplements

Mtc2.5

MOTS-c

Limited safety

Evidence

Evidence ScoreNot scored

Studies: 13

Meta-analyses: 1

Dosage & timing

Dosage:

No validated human dose exists. MOTS-c has never been dose-established in a published human interventional trial. Animal studies typically use ~0.5–15 mg/kg by injection in mice/rats, which does not translate to a human regimen. Anecdotal non-clinical injectable protocols circulated online have no clinical basis, no safety validation, and must not be read as a recommendation.

Best Time:

Any time

Can take on empty stomach

Form:

None — no form has validated human efficacy or an approved standard

What you'll notice

⚠️ No interventional human evidenceneutral

N/A

🩸 Insulin sensitivity / glucose metabolism (animal only)positive

Preclinical

🏃 Exercise capacity / physical performance (animal only)positive

Preclinical

Safety

Limited safety

Contraindications:

Pregnancy and breastfeeding — never studied; avoid entirely
Any use expecting a regulated, quality-controlled medicine — MOTS-c is a research chemical, not an approved drug or supplement
Diabetes medication without medical supervision — MOTS-c modulates glucose/insulin pathways in animals; unpredictable additive effects in humans are unstudied

Drug Interactions:

Glucose-lowering / antidiabetic drugs (insulin, sulfonylureas, metformin)

Side Effects:

Injection-related risks (infection, abscess, contamination from non-sterile product)Unknown long-term / off-target effects

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