Compare Supplements

There is no established or endorsed human dose for NDGA/chaparral as a longevity supplement, and this library does NOT provide a dosing protocol. NDGA's only strong efficacy data are in mice (the ITP lifespan studies dosed NDGA in the diet at ~2500-5000 ppm) and its metabolic data are in rodents (masoprocol ~10-80 mg/kg twice daily orally in rats; Scribner 2000) — neither is a human recommendation. The decisive consideration is harm: chaparral/NDGA has caused acute hepatitis, cirrhosis and fulminant liver failure requiring transplant in humans (Sheikh 1997), with no safe dose established and serious injury at doses people actually self-administered. Grey-market NDGA powder and chaparral products are of unverified identity, purity and dose, taken with no liver- or kidney-function monitoring.

With meals · with food

No human form is endorsed — NDGA/chaparral is a hepatotoxic research compound with no approved or recommended supplement form

• Any human use as a longevity or health supplement — NDGA/chaparral is HEPATOTOXIC and nephrotoxic, has caused fulminant liver failure requiring transplant, and has NO human efficacy evidence; it is a research compound, NOT a recommended dietary supplement
• Anyone with any liver disease, hepatitis, elevated liver enzymes, or a history of drug-induced liver injury — chaparral causes acute and chronic liver damage
• Anyone with kidney disease or impaired renal function — NDGA carries a nephrotoxicity signal (cystic nephropathy in animals)

• Hepatotoxic drugs (e.g. acetaminophen/paracetamol, methotrexate, isoniazid, amiodarone, statins)
• Alcohol
• Cytochrome-P450 substrates and anticoagulants (e.g. warfarin)