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Pdr4.0

PDRN / Polynucleotides (topical)

Moderate safety

Evidence

Evidence Score4/10

Studies: 6

Meta-analyses: 0

Dosage & timing

Dosage:

Topical 'salmon DNA' creams/serums are applied to skin per the product, but topical efficacy is essentially unproven (poor penetration of large DNA fragments). The evidence-backed forms are injectable (medical/aesthetic procedures performed by clinicians), which are outside the scope of a topical cosmetic entry. There is no oral or systemic consumer dose here. This library does not provide an ingestion protocol.

Best Time:

Any time

Can take on empty stomach

Form:

Injectable PDRN/PN under a clinician has the evidence; topical 'salmon DNA' skincare is largely unproven

What you'll notice

ℹ️ Injectable evidence ≠ topical productneutral

Throughout

💆 Skin rejuvenation (injectable)neutral

8-12 weeks

🩹 Wound healing (injectable, off-cosmetic-target)positive

Varies

Safety

Moderate safety

Contraindications:

This entry covers topical use only — injectable PDRN/PN is a clinician-administered procedure with its own risks
Known allergy to fish/salmon-derived products (source of PDRN)
Application to broken or irritated skin until healed

Drug Interactions:

Other leave-on actives

Side Effects:

Mild local irritation (topical)Fish-allergy reactionInjection-related effects (injectable forms only)

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