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There is no Western-approved or endorsed human dose. Phenibut is an unapproved GABA-B agonist with a serious dependence and withdrawal liability; this library does NOT provide a recommended dosing protocol. For context only, where it is prescribed abroad (Russia, as Anvifen/Fenibut/Noofen) typical anxiolytic doses are in the order of 250–500 mg up to a few times daily for short courses, and the pharmacology literature describes that range — but recreational/grey-market use commonly involves higher and escalating doses, and any regular use risks tolerance, dependence and a dangerous withdrawal syndrome. The safest dose is none; if it has been used regularly, do NOT stop abruptly — taper under medical supervision.

Evening

There is no Western-approved or endorsed form; phenibut is sold as grey-market oral powder/capsules and prescribed abroad as Anvifen/Fenibut/Noofen

• Concurrent use of alcohol or other CNS depressants (benzodiazepines, opioids, baclofen, sedating antihistamines, Z-drugs) — additive sedation and dangerous CNS/respiratory depression
• History of substance use disorder or dependence — phenibut carries a high dependence liability with rapid tolerance
• Abrupt discontinuation after regular use — risks a severe withdrawal syndrome (agitation, psychosis, delirium, seizures); requires a supervised taper

• Alcohol
• Benzodiazepines / Z-drugs / other sedative-hypnotics
• Opioids